Delirium

Protocol for a prospective cohort study to determine the multimodal biomarkers of delirium and new dementia after acute illness in older adults: ORCHARD-PS
Jasmine Ming Gan, Lily Elderton, Meenu Vijayakumar Sheela, Jessica Knight, John Louca, Sarah Evans, Kinza Shahab, Nicola G Lovett, Mary Sneade, Nycola Muchenje, Mariya Fenchyn, Davide Simonato, Aubretia McColl, Sarah Tamsin Pendlebury

BMJ Open Jun 2025, 15 (6) e102028; DOI: 10.1136/bmjopen-2025-102028
Transcutaneous auricular vagus nerve stimulation prevents postoperative delirium in elderly patients (VNSTAR): protocol for a multicentre, randomised controlled trial
Youxuan Wu, Xuan Hou, Tianyuan Wang, Xinyan Wang, Kangda Zhang, Fa Liang, Minyu Jian, Bo Wang, Haiyang Liu, Anxin Wang, Ruquan Han

BMJ Open May 2025, 15 (5) e099736; DOI: 10.1136/bmjopen-2025-099736
Outcomes associated with older patients who present or develop delirium in the emergency department: protocol for a systematic review and meta-analysis
Sarah King, Oddvar Uleberg, Sindre A Pedersen, Lars Petter Bjørnsen

BMJ Open May 2025, 15 (5) e095495; DOI: 10.1136/bmjopen-2024-095495
Factors contributing to the implementation of interventions to prevent and manage intensive care unit delirium: a systematic review protocol
Burak Kundakci, Katherine Louise Jones, Andrew Booth, Roxanne M Parslow, Andrew J Moore, Ben Gibbison, Maria Pufulete

BMJ Open Apr 2025, 15 (4) e093338; DOI: 10.1136/bmjopen-2024-093338
Effect of stellate ganglion block on delirium after major surgery in elderly patients: protocol for a randomised controlled study
Qi-hong Shen, Jun Zhang, Zhenping Li, Xiao-bin Wu, Gang Chen

BMJ Open Mar 2025, 15 (3) e093820; DOI: 10.1136/bmjopen-2024-093820
Protocol and design of the REPOSE study: a double-blinded, randomised, placebo-controlled trial to evaluate the efficacy of suvorexant to improve postoperative sleep and reduce delirium severity in older patients undergoing non-cardiac surgery
John Michael Fallon, Mona Hashemaghaie, Christy E Peterson, Dieplinh Tran, Sophie R Wu, Jonathan M Valdes, Nicole M Pedicini, Melissa E Adams, Marjorie Soltis, Wissam Mansour, Mary Cooter Wright, Karthik Raghunathan, Miriam M Treggiari, Cina Sasannejad, Michael J Devinney

BMJ Open Mar 2025, 15 (3) e091099; DOI: 10.1136/bmjopen-2024-091099
Effect of melatonin versus placebo for prevention of delirium among medically hospitalised patients: study protocol for a single-centre, double-blinded, randomised controlled trial (project RESTORE)
Juhaina Salim Al-Maqbali, Salim Al-Busaidi, Rajaa Saleh Al Farsi, Sara Al Rasbi, Khalfan Al Zeedy, Aisha Ramadhan Al Huraizi, Abdullah M Al Alawi

BMJ Open Feb 2025, 15 (2) e094195; DOI: 10.1136/bmjopen-2024-094195
Protocol for a meta-review of interventions to prevent and manage ICU delirium
Katherine Louise Jones, Burak Kundakci, Andrew Booth, Maria Pufulete, Ben Gibbison

BMJ Open Feb 2025, 15 (2) e090815; DOI: 10.1136/bmjopen-2024-090815
Effect of desflurane, sevoflurane or propofol on the incidence of postoperative delirium in older adults undergoing moderate- to high-risk major non-cardiac surgery: study protocol for a prospective, randomised, observer-blinded, clinical trial (RAPID-II trial)
Alexander Taschner, Edith Fleischmann, Barbara Kabon, Barbara Sinner, Christine Eckhardt, Katharina Horvath, Nikolas Adamowitsch, Nicole Hantakova, Beatrix Hochreiter, Oliver Zotti, Melanie Fraunschiel, Alexandra Graf, Christian Reiterer

BMJ Open Nov 2024, 14 (11) e092611; DOI: 10.1136/bmjopen-2024-092611
DELirium treatment with Transcranial Electrical Stimulation (DELTES): study protocol for a multicentre, randomised, double-blind, sham-controlled trial
Julia van der A, Yorben Lodema, Thomas H Ottens, Dennis J L G Schutter, Marielle H Emmelot-Vonk, Willem de Haan, Edwin van Dellen, Indira Tendolkar, Arjen J C Slooter

BMJ Open Nov 2024, 14 (11) e092165; DOI: 10.1136/bmjopen-2024-092165

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