molecular aspects

Does paired genetic testing improve targeted therapy choices and screening recommendations for patients with upper gastrointestinal cancers and their families? A prospective cohort of 42 patients
Kevin Tatunay, Stacey Cohen, Lorraine V Naylor, Cynthia L Handford, Angela Jacobson, Veena Shankaran, Brant Oelschlager, William M Grady, Britta Sjoding, Everett Lally, Lauren Facchini, Qin Sun, Mercy Y Laurino, Colin Pritchard, Eric Q Konnick, Marianne E Dubard-Gault

BMJ Open May 2025, 15 (5) e091745; DOI: 10.1136/bmjopen-2024-091745
A phase I, open-label, multicentre, first-in-human study to evaluate safety, pharmacokinetics and efficacy of AMG 404, a PD-1 inhibitor, in patients with advanced solid tumours
Timothy Price, Iwona Lugowska, Sant P Chawla, Gerald Falchook, Vivek Subbiah, Jose G Monzon, Hendrik-Tobias Arkenau, Mun Hui, Yasutoshi Kuboki, Rafal Dziadziuszko, Ryota Shibaki, Min Hee Hong, Daniel Tan, Caio Max Rocha Lima, Kejia Wang, Antreas Hindoyan, Weibing Shi, Hansen Wong, Mira Kistler, Hans Prenen

BMJ Open May 2025, 15 (5) e088578; DOI: 10.1136/bmjopen-2024-088578
Repurposing the FDA-approved anthelmintic pyrvinium pamoate for pancreatic cancer treatment: study protocol for a phase I clinical trial in early-stage pancreatic ductal adenocarcinoma
Francesca M Ponzini, Christopher W Schultz, Benjamin E Leiby, Shawnna Cannaday, T Yeo, James Posey, Wilbur B Bowne, Charles Yeo, Jonathan R Brody, Harish Lavu, Avinoam Nevler

BMJ Open Oct 2023, 13 (10) e073839; DOI: 10.1136/bmjopen-2023-073839
Safety and efficacy of Vitamin D₃ supplementation with Imatinib in Chronic Phase- Chronic Myeloid Leukaemia: an Exploratory Randomized Controlled Trial
Arkapal Bandyopadhyay, Sarika Palepu, Puneet Dhamija, Uttam Kumar Nath, Rituparna Chetia, Anamika Bakliwal, Sudeep Vaniyath, Debranjani Chattopadhyay, Shailendra Handu

BMJ Open Aug 2023, 13 (8) e066361; DOI: 10.1136/bmjopen-2022-066361
Protocol for a comprehensive prospective cohort study of trio-based whole-genome sequencing for underlying cancer predisposition in paediatric and adolescent patients newly diagnosed with cancer: the PREDICT study
Noemi Auxiliadora Fuentes Bolanos, Bhavna Padhye, Macabe Daley, Jacqueline Hunter, Kate Hetherington, Meera Warby, Eliza Courtney, Judy Kirk, Sarah Josephi-Taylor, Yuyan Chen, Frank Alvaro, Kristine Barlow-Stewart, Marie Wong-Erasmus, Paulette Barahona, Pamela Ajuyah, Ann-Kristin Altekoester, Vanessa J Tyrrell, Loretta M S Lau, Claire Wakefield, Dianne Sylvester, Katherine Tucker, Mark Pinese, Luciano Dalla Pozza, Tracey A O’Brien

BMJ Open May 2023, 13 (5) e070082; DOI: 10.1136/bmjopen-2022-070082
Prognostic value of miR-219-5p in relation to mortality in patients with small cell lung cancer: a retrospective, observational cohort study in China
Xiangmei Wu, Jigang Zhang, Xiaohui Zhang, Mengqi Xiang, Zhihua Xu, Zhijun Cao

BMJ Open Mar 2023, 13 (3) e064700; DOI: 10.1136/bmjopen-2022-064700
Prognostic significance of KMT2A-PTD in patients with acute myeloid leukaemia: a systematic review and meta-analysis
Wu Ye, Mingzhu Ma, Xia Wu, Jili Deng, Xiaoyan Liu, Xue Zheng, Yuping Gong

BMJ Open Feb 2023, 13 (2) e062376; DOI: 10.1136/bmjopen-2022-062376
Characteristics and prognostic values of traditional pathological parameters and advanced molecular subtypes in women in Beijing with operable breast cancer: a retrospective analysis
Qin Li, Li Li, Xiaoyue Jiang, Qi Du, Yingrui Li, Teng Li, Hong Gong, Bangwei Cao

BMJ Open Nov 2018, 8 (11) e021819; DOI: 10.1136/bmjopen-2018-021819
Protocol of an iterative qualitative study to develop a molecular testing decision aid for shared decision-making in patients with lung cancer after surgery
Xing Wei, Yangjun Liu, Hongfan Yu, Wei Dai, Ding Yang, Kunpeng Zhang, Jing Sun, Wei Xu, Ruoyan Gong, Qingsong Yu, Yang Pu, Yaqin Wang, Jia Liao, Yunfei Mu, Yuanqiang Zhang, Wenhong Feng, Qi Pan, Qiang Li, Qiuling Shi

BMJ Open Sep 2022, 12 (9) e061367; DOI: 10.1136/bmjopen-2022-061367
Extrapolating evidence for molecularly targeted therapies from common to rare cancers: a scoping review of methodological guidance
Doah Cho, Saskia Cheyne, Sarah J Lord, John Simes, Chee Khoon Lee

BMJ Open Jul 2022, 12 (7) e058350; DOI: 10.1136/bmjopen-2021-058350

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