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  • Study protocol for a randomised controlled trial evaluating the efficacy of dietary modulation of probiotics on nutritional status and antibody response to SARS-CoV-2 in Indonesian adolescents: gut-lung axis (DIVINE)

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Nutrition and metabolism
Protocol
Study protocol for a randomised controlled trial evaluating the efficacy of dietary modulation of probiotics on nutritional status and antibody response to SARS-CoV-2 in Indonesian adolescents: gut-lung axis (DIVINE)

Authors

  • Rina Agustina Department of Nutrition, Faculty of Medicine - Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, IndonesiaHuman Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia PubMed articlesGoogle scholar articles
  • Karina R. Ekawidyani Doctoral Study Program in Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaDepartment of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor, West Java, Indonesia PubMed articlesGoogle scholar articles
  • Mira Mutiyani Doctoral Study Program in Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaDepartment of Nutrition, Poltekkes Kemenkes Bandung, Bandung, West Java, Indonesia PubMed articlesGoogle scholar articles
  • Erfi Prafiantini Department of Nutrition, Faculty of Medicine - Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, IndonesiaHuman Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia PubMed articlesGoogle scholar articles
  • Triska S. Nindya Doctoral Study Program in Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaDepartment of Nutrition, Faculty of Public Health, Universitas Airlangga, Surabaya, East Java, Indonesia PubMed articlesGoogle scholar articles
  • Wahyu Damayanti Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia PubMed articlesGoogle scholar articles
  • Purwo S. Rejeki Physiology Division, Department of Medical Physiology and Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia PubMed articlesGoogle scholar articles
  • Lilik Djuari Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia PubMed articlesGoogle scholar articles
  • Emy Huriyati Department of Nutrition and Health, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia PubMed articlesGoogle scholar articles
  • Julie E. Bines Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, AustraliaDepartment of Gastroenterology and Clinical Nutrition, Royal Children’s Hospital Research Institute, Parkville, Victoria, AustraliaMurdoch Children’s Research Institute, Parkville, Victoria, Australia PubMed articlesGoogle scholar articles
  • Muhammad Juffrie Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia PubMed articlesGoogle scholar articles
  1. Correspondence to Prof. Dr. Rina Agustina; r.agustina{at}ui.ac.id; dr.rinaagustina{at}gmail.com
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Citation

Agustina R, Ekawidyani KR, Mutiyani M, et al
Study protocol for a randomised controlled trial evaluating the efficacy of dietary modulation of probiotics on nutritional status and antibody response to SARS-CoV-2 in Indonesian adolescents: gut-lung axis (DIVINE)
BMJ Open 2025;15:e087934. doi: 10.1136/bmjopen-2024-087934

Publication history

  • Received April 23, 2024
  • Accepted February 28, 2025
  • First published April 2, 2025.
Online issue publication 
April 02, 2025
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© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.