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  • NeoTRACK trial: Neoadjuvant TiRagolumab, Atezolizumab and Chemotherapy – dissection of IO- efficacy in NSCLC by longitudinal tracKing – protocol of a non-randomised, open-label, single-arm, phase II study

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Oncology
Protocol
NeoTRACK trial: Neoadjuvant TiRagolumab, Atezolizumab and Chemotherapy – dissection of IO- efficacy in NSCLC by longitudinal tracKing – protocol of a non-randomised, open-label, single-arm, phase II study

Authors

  • Romina M Roesch Department of Thoracic Surgery, Thoraxklinik at Heidelberg University Hospital, Heidelberg, GermanyTranslational Lung Research Center (TLRC-H), Member of German Center for Lung Research (DZL), Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Johannes Schnorbach Department of Thoracic Oncology, Thoraxklinik at Heidelberg University Hospital and National Center for Tumor Diseases (NCT), Heidelberg, Baden-Württemberg, Germany PubMed articlesGoogle scholar articles
  • Laura V Klotz Department of Thoracic Surgery, Thoraxklinik at Heidelberg University Hospital, Heidelberg, GermanyTranslational Lung Research Center (TLRC-H), Member of German Center for Lung Research (DZL), Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Raffaella Griffo Department of Thoracic Surgery, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Michael Thomas Translational Lung Research Center (TLRC-H), Member of German Center for Lung Research (DZL), Heidelberg, GermanyDepartment of Thoracic Oncology, Thoraxklinik at Heidelberg University Hospital and National Center for Tumor Diseases (NCT), Heidelberg, Baden-Württemberg, Germany PubMed articlesGoogle scholar articles
  • Albrecht Stenzinger Translational Lung Research Center (TLRC-H), Member of German Center for Lung Research (DZL), Heidelberg, GermanyInstitute of Pathology, Heidelberg University Hospital, Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Petros Christopoulos Translational Lung Research Center (TLRC-H), Member of German Center for Lung Research (DZL), Heidelberg, GermanyDepartment of Thoracic Oncology, Thoraxklinik at Heidelberg University Hospital and National Center for Tumor Diseases (NCT), Heidelberg, Baden-Württemberg, Germany PubMed articlesGoogle scholar articles
  • Michael Allgaeuer Translational Lung Research Center (TLRC-H), Member of German Center for Lung Research (DZL), Heidelberg, GermanyInstitute of Pathology, Heidelberg University Hospital, Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Marc Schneider Translational Lung Research Center (TLRC-H), Member of German Center for Lung Research (DZL), Heidelberg, GermanyTranslational Research Unit, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Martin Schuler Medical Faculty, University of Duisburg-Essen, Duisburg-Essen, GermanyDepartment of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, GermanyNCT West, National Center for Tumor Diseases (NCT), Essen, Germany PubMed articlesGoogle scholar articles
  • Marcel Wiesweg Medical Faculty, University of Duisburg-Essen, Duisburg-Essen, GermanyNCT West, National Center for Tumor Diseases (NCT), Essen, GermanyDepartment of Medical Oncology, University Hospital Essen, Essen, Germany PubMed articlesGoogle scholar articles
  • Alexander Schramm Medical Faculty, University of Duisburg-Essen, Duisburg-Essen, GermanyNCT West, National Center for Tumor Diseases (NCT), Essen, GermanyDepartment of Medical Oncology, University Hospital Essen, Essen, Germany PubMed articlesGoogle scholar articles
  • Servet Bölükbas Medical Faculty, University of Duisburg-Essen, Duisburg-Essen, GermanyNCT West, National Center for Tumor Diseases (NCT), Essen, GermanyDepartment of Thoracic Surgery, University Duisburg-Essen, Essen, Germany PubMed articlesGoogle scholar articles
  • Fabian Doerr Medical Faculty, University of Duisburg-Essen, Duisburg-Essen, GermanyNCT West, National Center for Tumor Diseases (NCT), Essen, GermanyDepartment of Thoracic Surgery, University Duisburg-Essen, Essen, Germany PubMed articlesGoogle scholar articles
  • Balazs Hegedüs Medical Faculty, University of Duisburg-Essen, Duisburg-Essen, GermanyNCT West, National Center for Tumor Diseases (NCT), Essen, GermanyDepartment of Thoracic Surgery, University Duisburg-Essen, Essen, Germany PubMed articlesGoogle scholar articles
  • Jelena Cvetkovic Department of Thoracic Oncology, Thoraxklinik at Heidelberg University Hospital and National Center for Tumor Diseases (NCT), Heidelberg, Baden-Württemberg, Germany PubMed articlesGoogle scholar articles
  • Marietta Kirchner Institute of Medical Biometry, Universitätsklinikum Heidelberg, Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Martin E Eichhorn Department of Thoracic Surgery, Thoraxklinik at Heidelberg University Hospital, Heidelberg, GermanyTranslational Lung Research Center (TLRC-H), Member of German Center for Lung Research (DZL), Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Hauke Winter Department of Thoracic Surgery, Thoraxklinik at Heidelberg University Hospital, Heidelberg, GermanyTranslational Lung Research Center (TLRC-H), Member of German Center for Lung Research (DZL), Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Farastuk Bozorgmehr Translational Lung Research Center (TLRC-H), Member of German Center for Lung Research (DZL), Heidelberg, GermanyDepartment of Thoracic Oncology, Thoraxklinik at Heidelberg University Hospital and National Center for Tumor Diseases (NCT), Heidelberg, Baden-Württemberg, Germany PubMed articlesGoogle scholar articles
  • Florian Eichhorn Department of Thoracic Surgery, Thoraxklinik at Heidelberg University Hospital, Heidelberg, GermanyTranslational Lung Research Center (TLRC-H), Member of German Center for Lung Research (DZL), Heidelberg, Germany PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Florian Eichhorn; florian.eichhorn{at}gmx.de
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Citation

Roesch RM, Schnorbach J, Klotz LV, et al
NeoTRACK trial: Neoadjuvant TiRagolumab, Atezolizumab and Chemotherapy – dissection of IO- efficacy in NSCLC by longitudinal tracKing – protocol of a non-randomised, open-label, single-arm, phase II study
BMJ Open 2025;15:e096617. doi: 10.1136/bmjopen-2024-096617

Publication history

  • Received November 14, 2024
  • Accepted March 5, 2025
  • First published March 27, 2025.
Online issue publication 
March 27, 2025
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© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.