Adoptive immunotherapy with natural killer cells from peripheral blood CD34+ stem cells to prevent hepatocellular carcinoma recurrence after curative hepatectomy: a study protocol for an open-label, single-arm phase I study

Masahiro Ohira; Tsuyoshi Kobayashi; Yuka Tanaka; Yuki Imaoka; Koki Sato; Koki Imaoka; Ryosuke Nakano; Marlen Doskali; Jinlian Piao; Mayuna Nakamura; Tetsumi Yoshida; Tatsuo Ichinohe; Reo Kawano; Kenichi Yoshimura; Keiko Ueda; Natsuko Tamura; Taizo Hirata; Michio Imamura; Hiroshi Aikata; Naoki Tanimine; Shintaro Kuroda; Hiroyuki Tahara; Kentaro Ide; Hideki Ohdan

doi:10.1136/bmjopen-2022-064526

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Adoptive immunotherapy with natural killer cells from peripheral blood CD34⁺ stem cells to prevent hepatocellular carcinoma recurrence after curative hepatectomy: a study protocol for an open-label, single-arm phase I study

Authors

Masahiro Ohira Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, JapanMedical Center for Translational and Clinical Research, Hiroshima University, Hiroshima, Japan PubMed articles Google scholar articles
Tsuyoshi Kobayashi Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan PubMed articles Google scholar articles
Yuka Tanaka Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan PubMed articles Google scholar articles
Yuki Imaoka Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan PubMed articles Google scholar articles
Koki Sato Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan PubMed articles Google scholar articles
Koki Imaoka Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan PubMed articles Google scholar articles
Ryosuke Nakano Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan PubMed articles Google scholar articles
Marlen Doskali Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan PubMed articles Google scholar articles
Jinlian Piao Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan PubMed articles Google scholar articles
Mayuna Nakamura Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan PubMed articles Google scholar articles
Tetsumi Yoshida Department of Hematology and Oncology, Hiroshima University Hospital, Hiroshima, Japan PubMed articles Google scholar articles
Tatsuo Ichinohe Department of Hematology and Oncology, Hiroshima University Hospital, Hiroshima, Japan PubMed articles Google scholar articles
Reo Kawano Clinical Research Center, Hiroshima University Hospital, Hiroshima, Japan PubMed articles Google scholar articles
Kenichi Yoshimura Medical Center for Translational and Clinical Research, Hiroshima University, Hiroshima, Japan PubMed articles Google scholar articles
Keiko Ueda Clinical Research Center, Hiroshima University Hospital, Hiroshima, Japan PubMed articles Google scholar articles
Natsuko Tamura Clinical Research Center, Hiroshima University Hospital, Hiroshima, Japan PubMed articles Google scholar articles
Taizo Hirata Clinical Research Center, Hiroshima University Hospital, Hiroshima, Japan PubMed articles Google scholar articles
Michio Imamura Department of Gastroenterology, Hiroshima University, Hiroshima, Japan PubMed articles Google scholar articles
Hiroshi Aikata Department of Gastroenterology, Hiroshima University, Hiroshima, Japan PubMed articles Google scholar articles
Naoki Tanimine Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan PubMed articles Google scholar articles
Shintaro Kuroda Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan PubMed articles Google scholar articles
Hiroyuki Tahara Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan PubMed articles Google scholar articles
Kentaro Ide Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan PubMed articles Google scholar articles
Hideki Ohdan Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, JapanClinical Research Center, Hiroshima University Hospital, Hiroshima, Japan PubMed articles Google scholar articles

Correspondence to Dr Hideki Ohdan; hohdan{at}hiroshima-u.ac.jp

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Citation

Ohira M, Kobayashi T, Tanaka Y, et al

BMJ Open 2022;12:e064526. doi: 10.1136/bmjopen-2022-064526

Publication history

Received May 9, 2022
Accepted September 30, 2022
First published November 21, 2022.

Online issue publication

December 29, 2023

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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