Clinical predictors of flare and drug-free remission in rheumatoid arthritis: preliminary results from the prospective BIO-FLARE experimental medicine study

Fiona Rayner; Shaun Hiu; Andrew Melville; Theophile Bigirumurame; Amy Anderson; Bernard Dyke; Sean Kerrigan; Andrew McGucken; Jonathan Prichard; Mohadeseh Shojaei Shahrokhabadi; Catharien M U Hilkens; Christopher D Buckley; Iain B McInnes; Wan-Fai Ng; Carl Goodyear; Dawn Teare; Andrew Filer; Stefan Siebert; Karim Raza; Arthur Pratt; Kenneth F Baker; John Isaacs

doi:10.1136/bmjopen-2024-092478

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Rheumatology

Original research

Clinical predictors of flare and drug-free remission in rheumatoid arthritis: preliminary results from the prospective BIO-FLARE experimental medicine study

Authors

Fiona Rayner Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UKMusculoskeletal Unit, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Shaun Hiu Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UKNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Andrew Melville Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK PubMed articles Google scholar articles
Theophile Bigirumurame Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Amy Anderson Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Bernard Dyke Institute of Inflammation and Ageing, NIHR Birmingham Biomedical Research Centre, Birmingham, UK PubMed articles Google scholar articles
Sean Kerrigan Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK PubMed articles Google scholar articles
Andrew McGucken Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK PubMed articles Google scholar articles
Jonathan Prichard Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Mohadeseh Shojaei Shahrokhabadi Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Catharien M U Hilkens Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Christopher D Buckley Institute of Inflammation and Ageing, NIHR Birmingham Biomedical Research Centre, Birmingham, UKKennedy Institute of Rheumatology, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Iain B McInnes Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK PubMed articles Google scholar articles
Wan-Fai Ng Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UKMusculoskeletal Unit, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Carl Goodyear Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK PubMed articles Google scholar articles
Dawn Teare Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Andrew Filer Institute of Inflammation and Ageing, NIHR Birmingham Biomedical Research Centre, Birmingham, UK PubMed articles Google scholar articles
Stefan Siebert Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UKNHS Greater Glasgow and Clyde, Glasgow, UK PubMed articles Google scholar articles
Karim Raza Institute of Inflammation and Ageing, NIHR Birmingham Biomedical Research Centre, Birmingham, UKSandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK PubMed articles Google scholar articles
Arthur Pratt Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UKMusculoskeletal Unit, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Kenneth F Baker Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UKMusculoskeletal Unit, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK PubMed articles Google scholar articles
John Isaacs Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UKMusculoskeletal Unit, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK PubMed articles Google scholar articles

Correspondence to Professor John Isaacs; john.isaacs{at}ncl.ac.uk

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Citation

Rayner F, Hiu S, Melville A, et al

Clinical predictors of flare and drug-free remission in rheumatoid arthritis: preliminary results from the prospective BIO-FLARE experimental medicine study

BMJ Open 2025;15:e092478. doi: 10.1136/bmjopen-2024-092478

Publication history

Received August 15, 2024
Accepted March 21, 2025
First published April 9, 2025.

Online issue publication

April 09, 2025

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© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY. Published by BMJ Group. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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