Yang X, He X, Pan D, et al. Intra-arterial alteplase for acute ischaemic stroke after mechanical thrombectomy (PEARL): rationale and design of a multicentre, prospective, open-label, blinded-endpoint, randomised controlled trial. BMJ Open 2024;14:e091059. doi: 10.1136/bmjopen-2024091059

This article was previously published with an error.

The follow-up visit at ‘48±12 hours’ was inadvertently omitted from ‘Follow-up Procedures’ under the Methods section. To accurately reflect all key assessment points, the text has been updated to:

Study visits will occur at 24±12 hours, 48±12 hours, day 7±1 or at discharge (whichever occurs first), and day 90±7. The follow-up schedule is displayed in table 1.

Accordingly, table 1 has been updated to include the missing ‘48±12 hours after randomisation’ visit, during which NIHSS scores, adverse event monitoring, and concomitant medication use are documented.

The missing ‘48±12 hours’ follow-up visit has also been added to the timeline in figure 2, to align with the follow-up schedule.

Figure 2 Study design of PEARL trial. AIS, acute ischaemic stroke; ASPECTS, Alberta Stroke Program Early CT Score; CTA, CT angiography; CTP, CT perfusion imaging; EQ-5D-5L, EuroQoL 5-Dimensions 5-Level Questionnaire; eTICI, expanded Thrombolysis in Cerebral Infarction; ICA, internal carotid artery; LVO, large-vessel occlusion; MRA, magnetic resonance angiography; mRS, modified Rankin Scale; MT, mechanical thrombectomy; NCCT, non-contrast CT; NIHSS, National Institute of Health Stroke Scale; PWI, perfusion-weighted imaging.