Protocol for the development of a tool (INSPECT-SR) to identify problematic randomised controlled trials in systematic reviews of health interventions

Jack Wilkinson; Calvin Heal; George A Antoniou; Ella Flemyng; Zarko Alfirevic; Alison Avenell; Ginny Barbour; Nicholas J L Brown; John Carlisle; Mike Clarke; Patrick Dicker; Jo C Dumville; Andrew Grey; Steph Grohmann; Lyle Gurrin; Jill Alison Hayden; James Heathers; Kylie Elizabeth Hunter; Toby Lasserson; Emily Lam; Sarah Lensen; Tianjing Li; Wentao Li; Elizabeth Loder; Andreas Lundh; Gideon Meyerowitz-Katz; Ben W Mol; Neil E O'Connell; Lisa Parker; Barbara K Redman; Lene Seidler; Kyle A Sheldrick; Emma Sydenham; David Torgerson; Madelon van Wely; Rui Wang; Lisa Bero; Jamie J Kirkham

doi:10.1136/bmjopen-2024-084164

Article info

Research methods

Protocol

Protocol for the development of a tool (INSPECT-SR) to identify problematic randomised controlled trials in systematic reviews of health interventions

Authors

Jack Wilkinson Centre for Biostatistics, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK PubMed articles Google scholar articles
Calvin Heal Centre for Biostatistics, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK PubMed articles Google scholar articles
George A Antoniou Manchester Vascular Centre, Manchester University NHS Foundation Trust, Manchester, UKDivision of Cardiovascular Sciences, School of Medical Sciences, Manchester Academic Health Science Centre, The University of Manchester Faculty of Biology Medicine and Health, Manchester, UK PubMed articles Google scholar articles
Ella Flemyng Evidence Production and Methods Directorate, Cochrane, London, UK PubMed articles Google scholar articles
Zarko Alfirevic Department of Women's and Children's Health, University of Liverpool, Liverpool, UK PubMed articles Google scholar articles
Alison Avenell Health Services Research Unit, University of Aberdeen, Aberdeen, UK PubMed articles Google scholar articles
Ginny Barbour Medical Journal of Australia, Sydney, New South Wales, Australia PubMed articles Google scholar articles
Nicholas J L Brown Department of Psychology, Linnaeus University, Växjö, Sweden PubMed articles Google scholar articles
John Carlisle Anaesthesia and Critical Care, Torbay Hospital, Torquay, UK PubMed articles Google scholar articles
Mike Clarke Northern Ireland Methodology Hub, Queen's University Belfast, Belfast, UK PubMed articles Google scholar articles
Patrick Dicker Department of Epidemiology and Public Health, Royal College of Surgeons in Ireland, Dublin, Ireland PubMed articles Google scholar articles
Jo C Dumville Division of Nursing, Midwifery and Social Work, School of Health Sciences, The University of Manchester, Manchester, UKNIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK PubMed articles Google scholar articles
Andrew Grey Department of Medicine, University of Auckland, Auckland, New Zealand PubMed articles Google scholar articles
Steph Grohmann Evidence Production and Methods Directorate, Cochrane, London, UK PubMed articles Google scholar articles
Lyle Gurrin School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia PubMed articles Google scholar articles
Jill Alison Hayden Community Health & Epidemiology, Dalhousie University, Halifax, Nova Scotia, CanadaDepartment of Community Health & Epidemiology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada PubMed articles Google scholar articles
James Heathers SafeBeat Rx Inc, St Louis, Missouri, USA PubMed articles Google scholar articles
Kylie Elizabeth Hunter Evidence Integration, NHMRC Clinical Trials Centre, University of Sydney, Sydney, New South Wales, Australia PubMed articles Google scholar articles
Toby Lasserson Evidence Production and Methods Directorate, Cochrane, London, UK PubMed articles Google scholar articles
Emily Lam Independent Lay Member, Cheshire, UK PubMed articles Google scholar articles
Sarah Lensen Department of Obstetrics and Gynaecology, Royal Women’s Hospital, University of Melbourne, Melbourne, Victoria, Australia PubMed articles Google scholar articles
Tianjing Li Department of Ophthalmology, University of Colorado, Denver, Colorado, USA PubMed articles Google scholar articles
Wentao Li Department of Obstetrics and Gynecology, Monash University, Clayton, Victoria, Australia PubMed articles Google scholar articles
Elizabeth Loder BMJ Publishing, London, UKDepartment of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA PubMed articles Google scholar articles
Andreas Lundh Centre of Evidence-Based Medicine Odense and Cochrane Denmark, Department of Clinical Research, University of Southern Denmark, Odense, DenmarkDepartment of Respiratory Medicine and Infectious Diseases, Copenhagen University Hospital—Bispebjerg and Frederiksberg, Kobenhavn, Denmark PubMed articles Google scholar articles
Gideon Meyerowitz-Katz School of Health and Society, University of Wollongong, Wollongong, New South Wales, Australia PubMed articles Google scholar articles
Ben W Mol Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia PubMed articles Google scholar articles
Neil E O'Connell Department of Clinical Science, Brunel University, Uxbridge, UKCentre for Health and Wellbeing across the Lifecourse, Dept of Health Sciences, Brunel University, London, UK PubMed articles Google scholar articles
Lisa Parker School of Pharmacy, Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia PubMed articles Google scholar articles
Barbara K Redman Division of Medical Ethics, New York University Grossman School of Medicine, New York, New York, USA PubMed articles Google scholar articles
Lene Seidler Evidence Integration, NHMRC Clinical Trials Centre, University of Sydney, Sydney, New South Wales, Australia PubMed articles Google scholar articles
Kyle A Sheldrick Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia PubMed articles Google scholar articles
Emma Sydenham Cochrane Central Production Service, Cochrane, London, UK PubMed articles Google scholar articles
David Torgerson York Trials Unit, Dept of Health Sciences, University of York, York, UK PubMed articles Google scholar articles
Madelon van Wely Cochrane Gynaecology and Fertility Satellite and Cochrane Sexually Transmitted Infection Group, Cochrane, Duivendrecht, The NetherlandsReproduction and Development Research Institute, Amsterdam University Medical Center, Amsterdam, The Netherlands PubMed articles Google scholar articles
Rui Wang Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia PubMed articles Google scholar articles
Lisa Bero Center for Bioethics and Humanities, University of Colorado—Anschutz Medical Campus, Denver, Colorado, USA PubMed articles Google scholar articles
Jamie J Kirkham Centre for Biostatistics, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK PubMed articles Google scholar articles

Correspondence to Jack Wilkinson; jack.wilkinson{at}manchester.ac.uk

View Full Text

Citation

Wilkinson J, Heal C, Antoniou GA, et al

Protocol for the development of a tool (INSPECT-SR) to identify problematic randomised controlled trials in systematic reviews of health interventions

BMJ Open 2024;14:e084164. doi: 10.1136/bmjopen-2024-084164

Publication history

Received January 11, 2024
Accepted January 30, 2024
First published March 11, 2024.

Online issue publication

March 11, 2024

Previous versions

Review history

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Copyright information

© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

Log in using your username and password

Main menu

Log in using your username and password

You are here

Authors

Citation

Publication history

Request permissions

Copyright information

Read the full text or download the PDF:

Log in using your username and password