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  • Alanyl-glutamine supplementation for Clostridioides difficile infection treatment (ACT): a double-blind randomised controlled trial study protocol

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Alanyl-glutamine supplementation for Clostridioides difficile infection treatment (ACT): a double-blind randomised controlled trial study protocol
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  • Published on: 2 August 2023
    Bismuth treatment of C. difficile enteritis

    Dear sirs,
    Practically all therapeutic modalities for the treatment of C. difficile enteritis have one thing in common. They are hugely expensive limiting their use even in affluent societies. Alanyl-glutamine is an exciting approach, as it is a relatively simple molecule, and may therefore be cheaper.
    A very old treatment tool exists however, that has been very rarely studied or used in recent years: bismuth. There is data that it is effective in C. difficile enteritis, has very few negative effects and is dirt cheap. The latter is probably one of the reasons for the lack of motivation for research about it. The use of bismuth salts in treating C. difficile enteritis is something definitely worthy of further study. Besides the 100 plus years of experience with bismuth, no approval or licencing is necessary.
    Yours sincerely
    Z. Lengyel MD, PhD.

    Conflict of Interest:
    None declared.