Correlation between change in BP and change in eGFR in mL/min/1.73 m2/year (linear regression) (n=7283)
| 60–69 Years (n=3696) | 70–79 Years (n=2933) | ≥80 Years (n=654) | ||||
|---|---|---|---|---|---|---|
| β (95% CI) | p Value | β (95% CI) | p Value | β (95% CI) | p Value | |
| Systolic BP change (per mm Hg/year) | ||||||
| Unadjusted | 0.11 (0.058 to 0.16) | <0.001 | 0.14 (0.080 to 0.19) | <0.001 | 0.17 (0.052 to 0.29) | 0.005 |
| Adjusted* | 0.10 (0.052 to 0.15) | <0.001 | 0.13 (0.076 to 0.19) | <0.001 | 0.17 (0.048 to 0.29) | 0.006 |
| Adjusted† | 0.030 (−0.025 to 0.086) | 0.28 | 0.069 (0.006 to 0.13) | 0.031 | 1.2 (0.34 to 2.1) | 0.007 |
| Baseline BP pressure (per 10 mm Hg) | −0.15 (−0.22 to −0.074) | <0.001 | −0.14 (−0.23 to −0.042) | 0.005 | −0.11 (−0.37 to 0.15) | 0.42 |
| Baseline CCI (per point increase) | −0.21 (−0.28 to −0.13) | <0.001 | −0.28 (−0.36 to −0.19) | <0.001 | −0.10 (−0.29 to 0.083) | 0.28 |
| Baseline CV medication | −0.25 (−0.44 to −0.069) | 0.007 | −0.50 (−0.73 to −0.26) | <0.001 | −0.61 (−1.2 to −0.023) | 0.042 |
| Baseline eGFR (per mL/min/1.73 m2) | −0.015 (−0.021 to −0.008) | <0.001 | −0.021 (−0.030 to −0.013) | <0.001 | −0.013 (−0.035 to 0.009) | 0.24 |
| Interaction term ‘systolic BP change × baseline systolic BP’ | NS | NS | NS | NS | −0.079 (−0.14 to −0.014) | 0.018 |
| Diastolic BP change (per mm Hg/year) | ||||||
| Unadjusted | 0.16 (0.072 to 0.25) | <0.001 | 0.18 (0.073 to 0.29) | 0.001 | 0.38 (0.15 to 0.62) | 0.002 |
| Adjusted* | 0.15 (0.064 to 0.24) | 0.001 | 0.18 (0.069 to 0.28) | 0.001 | 0.37 (0.14 to 0.61) | 0.002 |
| Adjusted† | 0.11 (0.008 to 0.21) | 0.034 | 0.14 (0.019 to 0.25) | 0.023 | 0.42 (0.16 to 0.67) | 0.001 |
| Baseline diastolic BP (per 10 mm Hg) | −0.082 (−0.22 to 0.054) | 0.24 | 0.57 (0.048 to 1.1) | 0.032 | 0.25 (−0.20 to 0.71) | 0.27 |
| Baseline CCI (per point increase) | −0.22 (−0.29 to −0.14) | <0.001 | 0.91 (0.029 to 1.8) | 0.043 | −0.13 (−0.32 to 0.052) | 0.16 |
| Baseline CV medication | −0.31 (−0.50 to −0.13) | 0.001 | −0.55 (−0.78 to −0.32) | <0.001 | −0.66 (−1.2 to −0.080) | 0.026 |
| Baseline eGFR (per mL/min/1.73 m2) | −0.015 (−0.022 to −0.008) | <0.001 | −0.021 (−0.030 to −0.013) | <0.001 | −0.015 (−0.037 to 0.007) | 0.18 |
| Interaction term ‘baseline diastolic BP × baseline CCI’ | NS | NS | −0.15 (−0.27 to −0.041) | 0.008 | NS | NS |
| Pulse pressure change (per mm Hg/year) | ||||||
| Unadjusted | 0.092 (0.031 to 0.15) | 0.003 | 0.13 (0.062 to 0.20) | <0.001 | 0.11 (−0.038 to 0.25) | 0.15 |
| Adjusted* | 0.086 (0.025 to 0.15) | 0.006 | 0.12 (0.057 to 0.19) | <0.001 | 0.10 (−0.042 to 0.24) | 0.17 |
| Adjusted† | 0.17 (0.015 to 0.32) | 0.031 | 0.050 (−0.025 to 0.13) | 0.19 | 0.064 (−0.10 to 0.23) | 0.45 |
| Baseline pulse pressure (per 10 mm Hg) | −0.19 (−0.28 to −0.094) | <0.001 | −0.15 (−0.26 to −0.043) | 0.006 | −0.052 (−0.31 to 0.20) | 0.69 |
| Baseline CCI (per point increase) | −0.20 (−0.27 to −0.13) | <0.001 | −0.28 (−0.36 to −0.19) | <0.001 | −0.13 (−0.31 to 0.059) | 0.18 |
| Baseline CV medication | −0.27 (−0.46 to −0.091) | 0.003 | −0.52 (−0.75 to −0.28) | <0.001 | −0.62 (−1.2 to -0.026) | 0.041 |
| Baseline eGFR (per mL/min/1.73 m2) | −0.015 (−0.022 to −0.008) | <0.001 | −0.021 (−0.030 to −0.013) | <0.001 | −0.014 (−0.036 to 0.008) | 0.22 |
| Interaction term ‘pulse pressure change × baseline CCI’ | −0.052 (−0.096 to −0.009) | 0.018 | NS | NS | NS | NS |
*Adjusted for age and gender.
†Adjusted for gender, age at baseline, baseline CCI, baseline CV medication, time between the first and last eGFR measurement after 2002, baseline eGFR and baseline BP measurements.
BP, blood pressure; CCI, Charlson Comorbidity Index; CV, cardiovascular; eGFR, estimated glomerular filtration rate; NS, not significant.