Baseline BP as a predictor of change in eGFR in mL/min/1.73 m2/year (linear regression) (n=8636)
| 60–69 Years (n=4128) | 70–79 Years (n=3530) | ≥80 Years (n=978) | ||||
|---|---|---|---|---|---|---|
| β (95% CI) | p Value | β (95% CI) | p Value | β (95% CI) | p Value | |
| Systolic BP (per 10 mm Hg) | ||||||
| Unadjusted | −0.14 (−0.21 to −0.066) | <0.001 | −0.18 (−0.27 to −0.083) | <0.001 | −0.26 (−0.47 to −0.043) | 0.018 |
| Adjusted* | −0.14 (−0.21 to −0.064) | <0.001 | −0.19 (−0.29 to −0.094) | <0.001 | −0.27 (−0.49 to −0.055) | 0.014 |
| Adjusted† | −0.11 (−0.18 to −0.034) | 0.004 | −0.14 (−0.24 to −0.048) | 0.003 | −0.24 (−0.46 to −0.024) | 0.029 |
| CCI (per point increase) | −0.15 (−0.23 to −0.061) | 0.001 | −0.27 (−0.37 to −0.18) | <0.001 | 0.003 (−0.20 to 0.21) | 0.97 |
| CV medication | −0.28 (−0.49 to −0.073) | 0.008 | −0.57 (−0.85 to −0.29) | <0.001 | −0.49 (−1.1 to 0.17) | 0.14 |
| Baseline eGFR (per mL/min/1.73 m2) | −0.014 (−0.021 to −0.006) | <0.001 | −0.027 (−0.036 to −0.017) | <0.001 | −0.004 (−0.028 to 0.019) | 0.73 |
| Diastolic BP (per 10 mm Hg) | ||||||
| Unadjusted | −0.077 (−0.21 to 0.059) | 0.27 | −0.12 (−0.31 to 0.069) | 0.21 | −0.20 (−0.64 to 0.24) | 0.38 |
| Adjusted* | −0.090 (−0.23 to 0.045) | 0.19 | −0.16 (−0.35 to 0.032) | 0.10 | −0.22 (−0.66 to 0.23) | 0.34 |
| Adjusted† | −0.069 (−0.21 to 0.068) | 0.33 | −0.14 (−0.33 to 0.056) | 0.17 | −0.19 (−0.63 to 0.26) | 0.41 |
| CCI (per point increase) | −0.15 (−0.24 to −0.066) | <0.001 | −0.28 (−0.38 to −0.19) | <0.001 | 0.001 (−0.20 to 0.20) | 0.99 |
| CV medication | −0.33 (−0.53 to −0.12) | 0.002 | −0.61 (−0.88 to −0.33) | <0.001 | −0.58 (−1.2 to 0.065) | 0.078 |
| Baseline eGFR (per mL/min/1.73 m2) | −0.014 (−0.022 to −0.007) | <0.001 | −0.027 (−0.037 to −0.017) | <0.001 | −0.004 (−0.028 to 0.020) | 0.73 |
| Pulse pressure (per 10 mm Hg) | ||||||
| Unadjusted | −0.18 (−0.27 to −0.090) | <0.001 | −0.20 (−0.31 to −0.089) | <0.001 | −0.26 (−0.50 to −0.025) | 0.031 |
| Adjusted* | −0.17 (−0.26 to −0.081) | <0.001 | −0.20 (−0.32 to −0.092) | <0.001 | −0.27 (−0.51 to −0.033) | 0.026 |
| Adjusted† | −0.14 (−0.23 to −0.043) | 0.004 | −0.15 (−0.26 to −0.037) | 0.009 | −0.25 (−0.49 to −0.002) | 0.048 |
| CCI (per point increase) | −0.14 (−0.22 to −0.055) | 0.001 | −0.27 (−0.36 to −0.18) | <0.001 | 0.006 (−0.20 to 0.21) | 0.95 |
| CV medication | −0.30 (−0.51 to −0.087) | 0.005 | −0.59 (−0.86 to −0.31) | <0.001 | −0.51 (−1.16 to 0.14) | 0.12 |
| Baseline eGFR (per mL/min/1.73 m2) | −0.014 (−0.022 to −0.006) | <0.001 | −0.027 (−0.037 to −0.017) | <0.001 | −0.004 (−0.028 to 0.019) | 0.72 |
*Adjusted for age and gender.
†Adjusted for gender, age, baseline CCI, baseline CV medication, time between the first and last eGFR measurement after 2002 (≥5 years), baseline eGFR.
BP, blood pressure; CCI, Charlson Comorbidity Index; CV, cardiovascular; eGFR, estimated glomerular filtration rate.