Table 2

Cox proportional regression modelling of risk of 1-year and long-term all-cause mortalities

	Age and sex + proANP/NT-proBNP			Multivariable + proANP/NT-proBNP*			Multivariable + proANP + NT-proBNP*
	HR	95% CI	p Value	HR	95% CI	p Value	HR	95% CI	p Value
1-year mortality
ProANP quartile (1 = reference)
2	1.01	0.59 to 1.72	0.967	0.90	0.52 to 1.55	0.704	0.80	0.45 to 1.43	0.445
3	1.42	0.85 to 2.37	0.185	1.24	0.73 to 2.11	0.424	0.91	0.49 to 1.69	0.767
4	3.11	1.90 to 5.08	<0.001	2.63	1.56 to 4.43	<0.001	1.47	0.76 to 2.83	0.248
Trend†	1.61	1.38 to 1.87	<0.001	1.53	1.30 to 1.81	<0.001	1.24	1.01 to 1.53	0.040
Pr. Log unit change	2.16	1.77 to 2.64	<0.001	2.05	1.64 to 2.56	<0.001	1.39	1.02 to 1.9	0.039
NT-ProBNP quartile (1 = reference)
2	1.20	0.68 to 2.11	0.520	1.02	0.58 to 1.80	0.947	1.10	0.60 to 2.03	0.752
3	1.93	1.13 to 3.30	0.017	1.72	1.00 to 2.97	0.051	1.60	0.84 to 3.06	0.154
4	3.82	2.27 to 6.43	<0.001	3.15	1.83 to 5.42	<0.001	2.41	1.22 to 4.75	0.011
Trend†	1.68	1.45 to 1.95	<0.001	1.60	1.36 to 1.88	<0.001	1.40	1.14 to 1.72	0.001
Pr. Log unit change	1.52	1.37 to 1.69	<0.001	1.52	1.34 to 1.71	<0.001	1.34	1.13 to 1.58	0.001
Long-term mortality
ProANP quartile (1 = reference)
2	1.20	0.97 to 1.49	0.095	1.11	0.89 to 1.38	0.350	1.08	0.86 to 1.36	0.521
3	1.31	1.04 to 1.63	0.019	1.12	0.89 to 1.41	0.325	1.01	0.78 to 1.32	0.916
4	2.42	1.93 to 3.04	<0.001	1.98	1.56 to 2.50	<0.001	1.50	1.11 to 2.02	0.008
Trend†	1.35	1.26 to 1.45	<0.001	1.26	1.17 to 1.36	<0.001	1.14	1.03 to 1.26	0.010
Pr. Log unit change	1.70	1.53 to 1.90	<0.001	1.54	1.37 to 1.74	<0.001	1.27	1.08 to 1.48	0.003
NT-ProBNP quartile (1 = reference)
2	1.15	0.92 to 1.42	0.219	1.02	0.82 to 1.27	0.848	1.03	0.81 to 1.30	0.829
3	1.34	1.08 to 1.68	0.009	1.22	0.97 to 1.53	0.082	1.12	0.86 to 1.46	0.406
4	2.36	1.89 to 2.95	0.<001	1.97	1.56 to 2.49	<0.001	1.59	1.18 to 2.13	0.002
Trend†	1.35	1.26 to 1.45	<0.001	1.28	1.19 to 1.38	<0.001	1.18	1.07 to 1.30	0.001
Pr. Log unit change	1.31	1.24 to 1.38	<0.001	1.26	1.19 to 1.34	<0.001	1.16	1.07 to 1.26	<0.001

*Adjusted for age, sex, alcohol, smoking, diabetes, history of congestive heart failure, history of pulmonary disease, history of liver disease, haemoglobin, ejection fraction below 50% and New York Heart Association functional classification 3 or 4.
†Trend across quartiles.
CVD, cardiovascular disease.