Baseline characteristics according to proANP quartiles
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | p Value | |
|---|---|---|---|---|---|
| N | 335 | 337 | 332 | 333 | |
| proANP (pmol/L) (IQR) | 336 (138) | 594 (161) | 990 (258) | 2052 (1068) | <0.001 |
| 1-year mortality (%) | 25 (7.5) | 33 (9.8) | 57 (17.2) | 124 (37.2) | <0.001 |
| Long-term mortality (%) | 147 (44.8) | 213 (64.2) | 254 (78.4) | 312 (95.1) | <0.001 |
| Age (SD) | 58.5 (12.2) | 67.7 (12.6) | 75.7 (12.3) | 80.3 (9.5) | <0.001 |
| Male sex (%) | 172 (51.3) | 131 (38.9) | 108 (32.5) | 130 (39.0) | <0.001 |
| Smoking (%) | 257 (76.7) | 251 (74.5) | 226 (68.3) | 229 (69.6) | 0.012 |
| Alcohol (%) | 60 (18.0) | 43 (12.8) | 29 (8.8) | 19 (5.8) | <0.001 |
| Medical history of | |||||
| Diabetes (%) | 35 (10.5) | 27 (8.0) | 47 (14.2) | 34 (10.2) | 0.464 |
| Hypertension (%) | 84 (25.1) | 77 (22.9) | 91 (27.5) | 102 (30.9) | 0.041 |
| Liver disease (%) | 9 (2.7) | 11 (3.3) | 9 (2.7) | 11 (3.3) | 0.739 |
| Pulmonary disease (%) | 60 (17.9) | 71 (21.1) | 62 (18.7) | 63 (19.1) | 0.90 |
| MI (%) | 17 (5.1) | 27 (8.0) | 35 (10.6) | 54 (16.4) | <0.001 |
| CHF (%) | 7 (2.1) | 23 (6.8) | 43 (13.0) | 90 (27.3) | <0.001 |
| AP (%) | 36 (10.8) | 68 (20.2) | 88 (26.6) | 95 (28.8) | <0.001 |
| Valve disease (%) | 3 (0.9) | 7 (2.1) | 9 (2.7) | 15 (4.6) | 0.003 |
| Findings | |||||
| NYHA class | |||||
| 3 (%) | 3 (0.9) | 13 (3.9) | 24 (7.3) | 58 (18.0) | <0.001 |
| 4 (%) | 0 (0.0) | 2 (0.6) | 0 (0.0) | 5 (1.5) | 0.025 |
| eGFR (SD) | 102.5 (30.4) | 90.6 (30.9) | 78.5 (26.7) | 63.1 (27.5) | <0.001 |
| Hgb (SD) | 8.5 (1.1) | 8.2 (1.2) | 8.0 (1.2) | 7.8 (1.3) | <0.001 |
| LVEF<50 (%) | 32 (9.6) | 42 (12.5) | 62 (18.7) | 114 (34.2) | <0.001 |
| NT-proBNP (pmol/L) (IQR) | 24 (32) | 60 (80) | 147.5 (160) | 477 (740) | <0.001 |
Values are mean±SD, median with IQR or n with per cent. Differences between quartiles are tested using Cochran-Armitage test for trend or analysis of variance when appropriate.
AP, angina pectoris; CHF, congestive heart failure; eGFR, estimated glomerual filtration rate; Hgb, haemoglobin; LVEF, left ventricular ejection fraction; MI, myocardial infarction; NYHA class, New York Heart Association functional classification.