Table 3

ORs for occurrence of knee osteoarthritis during the 3-year follow-up period versus mild cognitive impairment (MCI)

MMSE summary scoreUnivariate analysisLogistic regression model 1Logistic regression model 2
Explanatory variablesReferenceOR95% CIp ValueOR95% CIp ValueOR95% CIp Value
MMSE summary score+1 score0.760.68 to 0.85<0.001***0.850.73 to 0.970.015*0.830.72 to 0.960.010*
Other potential risk actors
Age (year)1 year1.091.06 to 1.13<0.001**1.101.06 to 1.14<0.001***
Gender0: men, 1: women4.362.33 to 8.16<0.001**4.021.50 to 10.740.006**
Region0: mountainous area, 1: coastal area0.780.45 to 1.350.3800.760.43 to 1.350.354
BMI (kg/m2)+1 kg/m21.231.12 to 1.34<0.001**1.221.11 to 1.34<0.001***
Grip strength (worse side) (kg)+1 kg1.010.96 to 1.060.730
Smoking0: exsmoker or never smoker,
1: current smoker
1.010.35 to 2.910.986
Alcohol consumption0: exdrinker or never drinker,
1: current drinker
1.110.60 to 2.040.746
Regular exercise after graduation from school0: no, 1: yes0.570.20 to 1.650.302
History of knee injuries0: no, 1: yes4.761.26 to 17.970.021*
MCIUnivariate analysisLogistic regression model 1Logistic regression model 2
Explanatory variables
MCI0: absence, 1 :presence5.521.57 to 19.340.008**4.591.18 to 17.70.027*4.901.20 to 20.050.027*
Other potential risk actors
Age (year)1 year 1.101.07 to 1.14<0.001**1.101.07 to 1.15<0.001***
Gender0: men, 1: women4.362.32 to 8.17<0.001**3.801.42 to 10.190.008**
Region0: mountainous area,
1: coastal area
0.750.44 to 1.300.3100.730.41 to 1.290.280
BMI (kg/m2)+1 kg/m21.231.13 to 1.35<0.001**1.231.12 to 1.34<0.001***
Grip strength (worse side) (kg)+ 1 kg1.000.96 to 1.050.870
Smoking0: exsmoker or never smoker, 1: current smoker1.080.38 to 3.120.885
Alcohol consumption0: exdrinker or never drinker, 1: current drinker1.100.59 to 2.020.770
Regular exercise after graduation from school0: no, 1: yes0.570.20 to 1.650.304
Past history of knee injuries0: no, 1: yes4.281.13 to 16.190.032*
  • *p<0.05, **p<0.01, ***p<0.001.

  • BMI, body mass index; n, number of subjects; MMSE, mini-mental state examination.