Table 1

Clinical profiles of patients with sporadic Creutzfeldt–Jakob disease

No	Age/sex	Diagnosis	Codon129/PrP^Sc	14-3-3/total τ	RT-QUIC	Pre-MRI duration (months)
1	69/M	Definite	MM/1	+/+	+	−2^*
2	77/F	Definite	MM/1	+/+	+	19
3	75/F	Definite	ND/1+2	+/+	+	3
4	65/M	Definite	MM/2	−/−	−	12
5	69/M	Probable	MM	ND	−	0.5
6	72/F	Probable	MM	ND	ND	0.5
7	77/F	Probable	MM	−/−	+	0.5
8	72/M	Probable	MM	ND	ND	1
9	63/M	Probable	MM	+/+	+	1.5
10	88/F	Probable	MM	ND	ND	1.5
11	75/M	Probable	MV	ND	ND	1.5
12	56/M	Probable	MM	+/+	+	2
13	67/M	Probable	MM	+/+	−	2
14	70/M	Probable	MM	+/+	+	2
15	70/F	Probable	MM	+/+	+	2
16	74/F	Probable	MM	+/+	−	2
17	84/F	Probable	MM	+/−	+	2
18	85/F	Probable	MM	−/+	+	2
19	49/F	Probable	ND	+/+	+	2
20	74/F	Probable	MV	+/+	+	2.5
21	54/F	Probable	ND	ND	ND	2.5
22	61/M	Probable	MM	ND	ND	3
23	72/F	Probable	MM	+/−	−	3
24	81/F	Probable	MM	−/−	+	3
25	70/M	Probable	MM	+/+	+	6
26	83/F	Probable	MM	+/+	ND	9
27	67/F	Probable	MM	+/+	−	15
28	84/F	Probable	MM	+/+	−	26
29	57/F	Possible	MM	ND	ND	4

↵* MRI was obtained 2 months before the symptom onset.2
MM, homozygous for methionine; MV, heterozygous with methionine and valine; ND, not done; RT-QUIC, real-time quaking-induced conversion.