Mean daily rates and observed/expected ratios of ingestion of a benzydamine hydrochloride-containing gynaecological preparation reported to the National Poison Control Centre in Milan in 2005–2010
| Period | Women | Men | ||||||||||
| Mean cases/day | 95% CI | Obs. | Exp. | O/E | 95% CI | Mean cases/day | 95% CI | Obs. | Exp. | O/E | 95% CI | |
| Pre-advertisement (1 January 2005–19 December 2009) | 0.04 | 0.03 to 0.05 | 67 | – | – | – | 0.01 | 0.01 to 0.02 | 20 | – | – | – |
| Advertisement (20 December 2009–6 March 2010) | 0.83 | 0.64 to 1.06 | 64 | 8.55* | 7.48 | 5.76 to 9.56 | 0.04 | 0.01 to 0.11 | 3 | 2.54* | 1.18 | 0.24 to 3.45 |
| Post-advertisement (7 March 2010–31 December 2010) | 0.19 | 0.14 to 0.24 | 56 | 18.87† | 2.97 | 2.24 to 3.85 | 0.02 | 0.00 to 0.04 | 5 | 5.63† | 0.89 | 0.29 to 2.07 |
↵* Calculated adjusting for a 3.0-fold increase of the population at risk of exposure based on the ratio between the mean number of packages/day sold in the advertisement and pre-advertisement periods (8381/2791), respectively.
↵† Calculated adjusting for a 1.7-fold increase of the population at risk of exposure based on the ratio between the mean number of packages/day sold in the post- and pre-advertisement periods (4764/2791), respectively.