Table 1

Timeline and schedule for enrolment, allocation and assessments

Timepoint	Study period
	Enrolment	Surgery	Postoperation				Close-out
	Pre-D1-3	D0	POD1	POD3	POD7	POD30	POD180
Enrolment:
Eligibility screen	X
Informed consent	X
Allocation	X
Assessments:
Baseline data	X
Frailty status	X					X
PPH assessment	X
Preoperative volume status		X
PIH assessment		X
eIOH assessment		X
Postoperative follow-up
Postoperative complications			X	X	X	X
POD-30 mortality						X
12-item WHODAS 2.0 score							X

12-item WHODAS 2.0, 12-item WHO Disability Assessment Schedule 2.0.32
eIOH, early intraoperative hypotension; PIH, post-induction hypotension; POD, postoperative day; PPH, postprandial hypotension.