Schedule of enrolment, intervention and assessment
| Time point follow-up | Preoperative 24 hours | Intraoperative | Postoperative | Discharge | 90 days | ||||
| 1 days | 2 days | 3 days | 4 days | 5 days | |||||
| Enrolment and randomisation | ✕ | ||||||||
| Interventions | ✕ | ✕ | ✕ | ✕ | ✕ | ||||
| Assessments | |||||||||
| Baseline variables | ✕ | ||||||||
| Surgical and anaesthesia conditions | ✕ | ||||||||
| 3D-CAM/CAM-ICU | ✕ | ✕ | ✕ | ✕ | ✕ | ✕ | |||
| MMSE/MoCA | ✕ | ✕ | |||||||
| AMTS/IADL | ✕ | ✕ | |||||||
| All adverse events and mortality | ✕ | ✕ | ✕ | ✕ | ✕ | ✕ | ✕ | ✕ | |
AMTS, Abbreviated Mental Test Score ; CAM-ICU, Confusion Assessment Method for Intensive Care Unit; 3D-CAM, 3-minute Diagnostic Interview for Confusion Assessment Method; IADL, Instrumental Activities of Daily Living; MMSE, Mini-mental State Examination; MoCA, Montreal Cognitive Assessment.