Inclusion and exclusion criteria of the MERCURI-2 trial
| Inclusion criteria | Exclusion criteria |
| Signed informed consent | T1D |
| Aged above 18 years | T2D with a BMI <25 kg/m2 and using multiple daily insulin injections (both short-acting and long-acting insulin) |
| Scheduled for elective cardiac surgery | History of diabetic ketoacidosis |
| Systolic blood pressure <100 mm Hg at time of inclusion | |
| Reduced kidney function at baseline with eGFR <20 mL/min at time of inclusion | |
| Current treatment with SGLT2 inhibitors | |
| Known or suspected allergy to trial products or other drugs in the same class | |
| Emergency surgery, defined as in need of surgery for medical reasons within 72 hours | |
| Woman of childbearing potential who is pregnant, breast feeding or intends to become pregnant or is not using adequate contraceptive methods |
BMI, body mass index; eGFR, estimated glomerular filtration rate; SGTL2, sodium-glucose cotransporter-2; T1D, type 1 diabetes; T2D, type 2 diabetes.