Table 1

Study schedule

TimepointStudy period
EnrolmentBaselinePostoperativeFollow-up
PreoperativeDay of surgeryDay 1Day 2Day 3Day 4Day 51 month
Enrolment
 Eligibility screenX
 Entry criteriaX
 Informed consentX
 DemographicsX
 Medical historyX
 AllocationX
Interventions
 AcetaminophenXXX
 PlaceboXXX
Assessments
 MMSEXX
 Confusion assessment method (3D-CAM/CAM-ICU)XXXXXX
 Pain score (NRS)XXXXX
 DRS-R-98XXXXX
 Medication administrationXXXXXX
 ICU and hospital stay lengthX
 Unplanned readmission and mortalityX
 Major postsurgical outcomesXX
  • 3D-CAM, 3-min diagnostic confusion assessment method; DRS-R-98, delirium rating scale-revised-98; ICU, intensive care unit; MMSE, mini-mental state examination; NRS, numerical rating scale.