Association between HSV-1 and Alzheimer’s disease assessed by conditional logistic regression (overall and stratified by age group)
| aOR | 95% CI | ||
| Overall | HSV-1 vs no HSV-1 | 1.80 | 1.65 to 1.96 |
| One comorbidity vs none | 1.30 | 1.28 to 1.32 | |
| ≥2 comorbidities vs none | 1.59 | 1.57 to 1.62 | |
| 50–70 years | HSV-1 vs no HSV-1 | 1.14 | 0.91 to 1.44 |
| One comorbidity vs none | 1.34 | 1.31 to 1.38 | |
| ≥2 comorbidities vs none | 1.54 | 1.50 to 1.59 | |
| 71–74 years | HSV-1 vs no HSV-1 | 1.51 | 1.27 to 1.80 |
| One comorbidity vs none | 1.34 | 1.31 to 1.37 | |
| ≥2 comorbidities vs none | 1.45 | 1.42 to 1.49 | |
| ≥75 years | HSV-1 vs no HSV-1 | 2.10 | 1.88 to 2.35 |
| One comorbidity vs none | 1.23 | 1.20 to 1.26 | |
| ≥2 comorbidities vs none | 1.77 | 1.73 to 1.81 |
aOR, adjusted ORs; HSV, herpes simplex virus.