Cox proportional hazards model using all-cause mortality as an anchor with QLF with cut-off of week 24 changes
| QLF changes in whole lung | Total patients (N=152) | Total deaths (n=11) (%) | HR (95% CI) | P value |
| Continuous*, % | 1.20 (1.08, 1.34) | 0.001 | ||
| Continuous*, mL | 1.01 (1.01, 1.02) | <0.001 |
| Week 24 QLF changes in whole lung | Total patients meeting listed threshold, n (%) | Total deaths meeting listed threshold, n (%) | HR (95% CI) | P value |
| ≥0% | 118 (78) | 9 (82) | 1.48 (0.31, 7.02) | 0.623 |
| ≥0 mL | 99 (65) | 9 (82) | 2.57 (0.55, 12.1) | 0.232 |
| Thresholds QLF, % | ||||
| ≥1% | 101 (66) | 9 (82) | 4.98 (1.00, 24.8) | 0.050 |
| ≥2% | 87 (57) | 8 (73) | 4.04 (1.06, 15.4) | 0.041 |
| ≥3% | 66 (43) | 6 (55) | 4.69 (1.24, 17.7) | 0.023 |
| ≥4% | 50 (33) | 5 (45) | 4.52 (1.18, 17.3) | 0.028 |
| QLF volume | ||||
| ≥20 mL | 84 (55) | 8 (73) | 6.37 (1.27, 32.0) | 0.024 |
| ≥22 mL | 83 (55) | 8 (73) | 6.38 (1.27, 32.0) | 0.024 |
| ≥24 mL | 81 (53) | 8 (73) | 6.83 (1.37, 34.2) | 0.019 |
| ≥26 mL | 80 (53) | 8 (73) | 7.63 (1.51, 38.6) | 0.014 |
Note: Mean change from previously modelled measurement variation of QLF of 0.4% (2.77×2×SD).
*The proportional hazards assumption is being examined and met using Schoenfield residuals.
QLF, Quantitative Lung Fibrosis score.