Table 1

PICO elements

PopulationWomen with ischaemic MR.
InterventionSurgical mitral valve repair or replacement.
ComparatorMen who undergo mitral valve surgery (repair or replacement) for ischaemic MR.
OutcomePrimary outcome: long-term (>1 year) mortality

  • If possible, mortality will be stratified by:

  • All-cause mortality

  • Cardiovascular mortality


Secondary outcomes:

  • Operative mortality

  • Mitral valve reintervention

  • Heart failure rehospitalisation

  • MR recurrence, as assessed by echocardiography

  • .MR, Mitral regurgitation; PICO, Population, Intervention, Comparator, Outcome.