GRADE levels of confidence in cumulative evidence
| Level | Definition |
| High | High level of confidence that the true effect lies close to the estimate of the effect |
| Moderate | Moderate confidence in the estimate of effect, meaning that the true effect is likely to be close to the estimate, but there is a possibility that it may be substantially different |
| Low | Limited confidence in the estimate of effect, suggesting that the true effect may be substantially different from the estimate |
| Very low | Very little confidence in the estimate of effect, indicating that the true effect is likely to be substantially different from the estimate |