Study schedule
| Preoperative medical examination (baseline) | Surgical procedure | 2-month follow-up | 6-month follow-up | 12-month follow-up | |
| Inclusion/exclusion criteria evaluation | X | ||||
| Informed consent signing | X | ||||
| Demographic data | X | ||||
| Medical history | X | ||||
| Randomisation | X | ||||
| WOMAC | X | X | X | X | |
| IKDC Subjective | X | X | X | X | |
| IKDC Objective | X | X | X | X | |
| KOOS | X | X | X | X | |
| PASS | X | X | X | X | |
| EQ-VAS | X | X | X | X | |
| Tegner | X | X | X | X | |
| Minimal clinically important difference | X | X | X | ||
| Patient expectation of the treatment | X | ||||
| Patient judgement on the treatment | X | ||||
| Adverse events reporting | X | X | X | X | |
| Medication tracking sheet | X | X | X | ||
| Radiographs and KL evaluation | X | X | |||
| 3T MR and WORMS | X | X | |||
| Blood sample collection | X | X | X | X | |
| SF collection and synovial membrane biopsy | X |
EQ-VAS, EuroQol-Visual Analogue Scale; IKDC, International Knee Documentation Committee; KL, Kellgren-Lawrence; KOOS, Knee Injury and Osteoarthritis Outcome score; MR, magnetic resonance; SF, synovial fluid; T, Tesla; WOMAC, Western Ontario and McMaster Universities Arthritis Index; WORMS, Whole-Organ MRI Score.