Comparisons for outcome measures (EQ-5D-5L, HADS, SPPB) for the BBS population (n=30) and the Norwegian normative data
| EQ-5D-5L domains | BBS (n=30) | Normative data (n=3120) | P value |
| Any problems, n (%) | Any problems, n (%)* | ||
| Mobility | 16 (53%) | 562 (18.0%) | <0.001 |
| Self-care | 7 (23%) | 227 (7.3%) | <0.001 |
| Usual activities | 16 (53%) | 756 (24.2%) | <0.001 |
| Pain/discomfort | 19 (63%) | 1937 (62.1%) | 0.888 |
| Anxiety/depression | 13 (43%) | 1104 (35.4%) | 0.365 |
| BBS, mean (SD) | Expected, mean (SD)* | ||
| EQ-5D-5L VAS scale (score 0–100) | 63.8 (21.5) | 77.9 (18.3) | <0.001 |
| EQ-5D-5L index score (score 0–1) | 0.79 (0.18) | 0.81 (0.20) | 0.585 |
| BBS, mean (SD) | Expected, mean (SD)† | ||
| HADS-total score | 5.00 (6.01) | 7.68 (5.66) n=40 648 | <0.01 |
| HADS-anxiety | 3.13 (3.90) | 4.40 (3.46) n=41 133 | 0.04 |
| HADS-depression | 1.87 (2.62) | 3.30 (2.96) n=39 573 | <0.01 |
| BBS, mean (SD) | Expected, mean (SD)‡ | ||
| SPPB-total score | 6.7 (3.5) | 11.4 (1.3) n=7474 | <0.001 |
Comparisons between our BBS population and the general Norwegian population were conducted using online calculators for two sample t-tests and χ2 tests.
*Derived from Garratt et al.41
†Derived from HUNT-4 study.44
‡Derived from Bergland et al.39
BBS, Bardet-Biedl syndrome; HADS, Hospital Anxiety and Depression Scale; SPPB, Short Physical Performance Battery; VAS, visual analogue scale.