Description of the primary research question addressed in the target trial (Clement et al 16)
| Objective: | Investigate whether long-term use of azithromycin is associated with respiratory benefits in young people with CF |
| Population: | CF patients aged older than 6 years and forced expiratory volume in 1 s (FEV1%) of 40% or more. |
| Exposure: | Oral azithromycin |
| Comparator: | Placebo pills |
| Primary outcome: | Change in FEV1% |
| Time: | 12 months |
| Setting: | Patients recruited from 18 CF accredited care centres in France |
| Main measure of effect: | Difference in change in FEV1% from baseline between treatment groups |
CF, cystic fibrosis.