Multivariable analyses of association between cardiovascular risk factors and the cognitive assessment results, older people living with HIV, Georgia, 2023 (n=122)
Assessment | Framingham risk score | Total cholesterol (units) | HDL (units) | Diabetes (yes/no) | ||||
β (95% CI) | p | β (95% CI) | p | β (95% CI) | p | β (95% CI) | p | |
MoCA | 0.001 (−0.08, 0.08) | 0.98 | 0.001 (−0.02, 0.03) | 0.7 | −0.02 (−0.09, 0.04) | 0.47 | 2.97 (−0.42, 6.36) | 0.09 |
TMT A | 0.35 (−0.12, 0.81) | 0.14 | 0.12 (−0.01, 0.24) | 0.07 | −0.08 (−0.44, 0.28) | 0.67 | −6.22 (−25.5, 13.1) | 0.53 |
TMT B | 1.65 (0.11, 3.19) | 0.04 | −0.2 (−0.6, 0.2) | 0.33 | 0.61 (−0.51, 1.73) | 0.28 | 4.92 (−53.22, 63.05) | 0.87 |
Semantic fluency | −0.02 (−0.23, 0.19) | 0.8 | 0.03 (−0.03, 0.08) | 0.32 | −0.14 (−0.29, 0.02) | 0.08 | 8.51 (0.46, 16.57) | 0.04 |
Letter fluency | −0.01 (−0.20, 0.17) | 0.9 | −0.05 (−0.10, 0.01) | 0.04 | 0.07 (−0.06, 0.21) | 0.29 | 11.41 (4.31, 18.50) | 0.002 |
Stroop Test 1 | −0.19 (−0.61, 0.23) | 0.4 | −0.05 (−0.16, 0.07) | 0.42 | −0.12 (−0.44, 0.20) | 0.45 | −6.98 (−23.84, 9.88) | 0.41 |
Stroop Test 2 | −0.20 (−0.53, 0.13) | 0.23 | −0.004 (−0.09, 0.08) | 0.92 | −0.20 (−0.44, 0.04) | 0.11 | 4.07 (−8.63, 16.78) | 0.53 |
Stroop Test 3 | −0.04 (−0.31, 0.22) | 0.7 | 0.02 (−0.05, 0.09) | 0.57 | −0.04 (−0.23, 0.16) | 0.721 | 1.07 (−9.44, 11.57) | 0.84 |
GPT | 1.02 (0.43, 1.60) | 0.001 | 0.01 (−0.15, 0.16) | 0.93 | −0.30 (−0.73, 0.13) | 0.17 | 8.69 (−14.10, 31.47) | 0.45 |
Note: Multiple linear regression models were adjusted for BMI, years of education, drug dependency, having enough income for basic needs, history of HCV infection, history of tuberculosis, history of stroke, history of COVID-19 and history of ever interrupting ART
GPT, Grooved Pegboard Test; HDL, high-density lipoprotein; HIV, human immunodeficiency virus; TMT, trail-making test.