Medication adherence
| No. | Reference | Non-adherence/ non-persistence | Follow-up | Measurement method | Threshold NA |
| Poor medication adherence | |||||
| Pharmacy ROM | |||||
| 1 | Cassar et al 45 | 9% | 1 M | Counting returned pills | NR |
| 2 | Haile et al 32 | 30% | 1.5 Y | Counting pills | <80% |
| 3 | Qvist et al 31 | 45%* | 5Y | National prescription register | Primary NA: filling prescription >120 days. Other: <80% |
| 4 | Wawruch et al 33 | 43% | 5 Y | Counting returned pills | <80% |
| Pharmacy and patient ROM | |||||
| 5 | Hess et al 30 | 8% | Md 28 M (IQR: 22–34) | Interview NVQ and counting returned pills | NR |
| Patient ROM | |||||
| 6 | Ferreira-González et al 46 | 2% | 1 Y | Interview (NVQ) | NR |
| 7 | Halle et al 36 | 26% | NR | Morisky Medication Adherence Scale | 8 points |
| 8 | Jivegård et al 48 | 26% | 3 M | Patient diary | NR |
| 9 | Kremers et al 49 | 5% | 1 Y | Morisky Medication Adherence Scale | 8 points |
| 10 | Weissler et al 29 | 10% | 30 M (up to 42 M) | Interview | NR |
| Primary non-adherence | |||||
| 1 | Qvist et al 31 | 31% | 6 M | National prescription register | Filling prescription >120 days |
| Secondary non-adherence | |||||
| Short-term secondary non-adherence | |||||
| Pharmacy ROM | |||||
| 1 | Cassar et al 45 | 9% | 1 M | Counting returned pills | NR |
| 2 | Haile et al 32 | 21% | 6 M | Counting pills | <80% |
| Patient ROM | |||||
| 1 | Jivegård | 26% | 3 M | Patient diary | NR |
| Long-term secondary outcome | |||||
| Pharmacy ROM | |||||
| 1 | Haile et al 32 | 14% | 1 Y | Counting pills | <80% |
| 2 | Qvist et al 31 | 20% | 5 Y | National prescription register | <80% |
| 3 | Wawruch et al 33 | 20% | 5 Y | Counting returned pills | <80% |
| Patient ROM | |||||
| 4 | Halle et al 36 | 26% | NR | Counting pills | <80% |
| 5 | Kremers et al 49 | 5% | 1 Y | Morisky Medication Adherence Scale | 8 points |
| Non-persistence† | |||||
| Pharmacy ROM | |||||
| 1 | Qvist et al 31 | 27% | 5 Y | National prescription register | <80% |
| 2 | Wawruch et al 33 | 33% | 5 Y | Counting returned pills | <80% |
| Pharmacy and patient ROM | |||||
| 3 | Hess et al 30 | 8% | Md 28 M (IQR 22–34) | Interview NVQ and counting returned pills | NR |
| Patient ROM | |||||
| 4 | Ferreira-González et al 46 | 2% | 1 Y | Interview (NVQ) | NR |
| 5 | Weissler et al 29 | 10% | 30 M (up to 42M) | Interview | NR |
*Non-persistence is excluded since the proportion of the patients who were non-adherent and non-persistent is lacking.
†Non-persistent due to patients’ decisions.
M, months; Md, median; NA, non-adherence; NR, not reported; NVQ, non-validated questionnaire; ROM, reported outcome measurements.