Table 1

Schedule of assessment

Domain	Measure	Screening	Baseline	During treatment	1-month follow-up	3-month follow-up
Eligibility	Demographic questionnaire	X	X
	Consent form	X
	Medical history	X
	MoCA	X
	Medication	X	X	X	X	X
Primary outcome	Visual Analogue Scale	X	X	X	X	X
Secondary outcomes	Brief Pain Inventory Short Form				X	X
	Blood sample—Inflammation markers		X		X	X
	Cognition		X		X	X
	Rivermead TBI symptoms				X	X
	Short Musculoskeletal Function Assessment				X	X
	Short Form Health Survey				X	X
	Pittsburgh Sleep Quality Index				X	X
	Beck’s Depression Inventory-II		X		X	X
	Beck’s Anxiety Inventory		X		X	X
Other	Pain Catastrophising Scale		X
	Treatment Expectation Questionnaire		X
	PTSD Checklist for DSM-5		X		X
	Treatment assignation hypothesis				X
	Opioid consumption	X	X	X	X	X
	Adverse events			X	X

DSM-5, The Diagnostic and Statistical Manual of Mental Illnesses; MoCA, Montreal Cognitive Assessment; PTSD, post-traumatic stress disorder; TBI, traumatic brain injury.