Minimum detectable effect sizes for outcomes
| SIRX study | Comparison | Mortality (HR) | Non-fatal OD (IRR) |
| SIRX-R Cohort | Frequent (weekly) vs infrequent (<weekly) use | 0.42 | 0.69 |
| SuperMIX Cohort | Frequent (≥50% all injections) vs no use | 0.3 | 0.58 |
| SuperMIX Cohort | Infrequent (<50% injections) vs no use | 0.37 | 0.64 |
IRR, incidence rate ratio; OD, overdose; SIRX-R, Supervised Injecting Room Registration Cohort; SuperMIX, Melbourne Injecting Drug User Cohort.