Table 1

Study timeline and procedures

Study timelineBaseline6-week follow-up visit12-week follow-up visit
Informed consent×
Demographics*×
Medical history×
Concomitant medications×××
Physical examination*×××
Office blood pressure measurement×××
24 hours ambulatory blood pressure monitor×××
Laboratory examination*××
PHQ-9 scores*××
GAD-7 scores*××
Compliance with medication*××
Adverse event record×××

  • Demographics: such as date of birth, sex, and ethnicity; Physical examination: including height, weight, waist circumference, breath rate, heart rate; Laboratory examination: including blood routine, AST, ALT, total bilirubin, direct bilirubin, indirect bilirubin, serum creatinine, triglyceride, total cholesterol, low density lipoprotein, high density lipoprotein, glucose, uric acid, sodium, potassium, chlorine, urinary albumin creatinine ratio;

  • Compliance with medication will be assessed by comparing the number of pills patients have left with the number of pills they have taken

  • GAD-7, Generalized Anxiety Disorder 7-Item Scale; PHQ-9, Patient Health Questionnaire-9.