Schematic overview of measurements during study visits
| Screening | Baseline visit | Rest visit | Exercise visit | |
| Participant-related information | ||||
| Informed consent | X | |||
| Assessment of inclusion and exclusion criteria | X | |||
| Anthropometrics | X | |||
| Medical history (including concomitant medications) | X | |||
| Clinical assessment | ||||
| Blood pressure | X | |||
| ECG | X | |||
| Bioimpedance | X (morning) | |||
| VO2peak | X | |||
| Efficacy outcomes | ||||
| Fasting blood samples+HbA1c | X | X | ||
| Post exercise/rest blood samples | X | X | ||
| Post ad libitum meal blood samples | X | X | ||
| VAS (appetite) | X | X | ||
| VAS (meal assessment) | X | X | ||
| SBFPT | X | X | ||
| Acute exercise bout | X | |||
| RPE (Borg scale) | X | |||
| Ad libitum meal | X | X | ||
| Questionnaires | ||||
| Socioeconomic status | X (morning) | |||
| Control of Eating Questionnaire | X | |||
| International Physical Activity Questionnaire | X (morning) | |||
| Morningness/Eveningness Questionnaire | X (morning) | |||
| Munich Chronotype Questionnaire | X (morning) | |||
| Pittsburgh Sleep Quality Index | X (morning) | |||
| Safety outcomes | ||||
| Adverse events | X | X | X | |
DXA, dual-energy X-ray absorptiometry; HbA1c, glycated haemoglobin; RPE, ratings of perceived exertion; SBFPT, Steno Biometric Food Preference Task; VAS, Visual Analogue Scale; VO2peak, peak oxygen consumption.