Table 2

Outcomes and assessments between 13 and 14-year olds

Primary outcomeGORD will be determined based on the following criteria:

  • Positive pH-(impedance)metry results obtained within the previous year.

  • And/or presence of histological peptic esophagitis lesions at oesophageal biopsies collected during the previous year.

  • And/or history of anti-reflux surgery.

Secondary outcomesQuality of life:

  • PedsQL total patient and parent scores

  • EA QoL total patient and parent scores

Nutritional status:

  • Z-score weight/height and height/age

  • Type of feeding (oral, enteral, both) (food avoidance)

Digestive status:

  • Current proton pump inhibitor treatment

  • Dysphagia (defined by sensations such as blockage leading to vomiting or the need to drink to pass food or slowness in eating)

  • GORD symptoms (regurgitation, vomiting, retrosternal pain and heartburn)

Respiratory status:

  • Frequency of cough

  • Asthma

  • Occurrence of exercise-induced symptoms (cough, dyspnoea)

  • Atopy

  • Wheezing

  • Stridor

  • Need for medications (corticosteroid, inhaled medications)

History from 6 years to adolescence:

  • Associated malformations discovered after 6 years

  • Gastrostomy placement and/or use after 6 years old

  • Characteristics of eventual GORD surgery (type, complications, cardial dilatation, relapse)

  • Oesogastroduodenoscopy (number, histology)

  • Repermeabilisation of the oesotracheal fistula (treatment, number, date)

  • Stenosis (date, dilatation, number, surgery)

  • Stricture (date, number and method of dilatation, surgery, use of corticosteroid)

Psychological or psychiatric follow-up neuro-orthopaedic outcomes:

  • Scoliosis

  • Kyphosis

  • Stature malposition

Speech therapy:

  • Oral/stomatology

  • Oral disorders

  • Speech disorders

  • Dental conditions

Education:

  • Physical/sport waiver

  • Adapted school rhythm

  • Specialised school

  • School absenteeism

Omic profile:

  • In oesophageal biopsies:

    • Protein abundances

    • Metabolite abundances

    • RNA profile

      • 3’RNA

      • miRNA

    • Methylation status

  • In blood:

    • Metabolite abundance

    • Protein abundance

    • miRNA profile

Other assessmentsParents’ height parents’ socio-cultural level and highest diploma attained city of residence

  • EA QoL, disease-specific QoL questionnaire; GORD, gastro-oesophageal reflux disease; PedsQL, Pediatric Quality of Life Inventory.