Table 1

Eligibility and exclusion criteria

Patients with oesophageal atresia
Eligibility criteria

  • Born with OA in France (metropolitan or overseas)

  • Underwent oesophageal anastomosis at one of the participating centres

  • Included in the ReNaTo registry

  • Age between 13 and 14 years during the inclusion period

  • Willingness to participate.

  • Patient with social security

Blood sub-study:

  • Upper GI endoscopy performed as part of care between 13 and 14 years of age with oesophageal mucosal biopsy sampling

  • Consent for blood sampling

Exclusion criteria

  • Participation in an interventional trial (simultaneously or up to 3 months before inclusion

  • Oesophageal replacement

Controls
Eligibility criteria

  • Upper GI endoscopy performed as part of care between 10 and 14 years of age with oesophageal mucosal biopsy sampling

  • Underwent esophagogastroduodenoscopy (EGD) as part of routine care for any digestive symptom to exclude organic aetiology (peptic esophagitis, gastritis, eosinophilic esophagitis or ulcer)

  • EGD findings and histology are normal

  • Absence of concurrent progressive chronic disease

  • Provision of signed study consent

Exclusion criteria

  • Known underlying disease

  • OA, oesophageal atresia.