Most frequent (top 3) Wilson disease (WD) manifestations by subtype
| Manifestations | N | % subtype | % overall cohort (n=2115) |
| Hepatic subtype* (n=1202) | |||
| Liver signs and symptoms | 1092 | 90.8% | 51.6% |
| Cirrhosis | 456 | 37.9% | 21.6% |
| Hepatitis | 347 | 28.9% | 16.4% |
| Neurologic subtype* (n=1206) | |||
| Cognitive defects | 611 | 50.7% | 28.9% |
| Ataxia and gait abnormalities | 436 | 36.2% | 20.6% |
| Dysphagia | 328 | 27.2% | 15.5% |
| Psychiatric subtype* (n=1003) | |||
| Mood disorders | 867 | 86.4% | 41.0% |
| Mix of symptoms, children | 224 | 22.3% | 10.6% |
| Paranoia and schizophrenia | 199 | 19.8% | 9.4% |
*These groups are not mutually exclusive.