Table 2

Outcome assessments

Outcome	Measurements	Timepoint
Primary outcome
Postoperative delirium	3D-CAM/CAM-ICU	Evening on the day of surgery and morning and evening of the first five postoperative days
Secondary outcomes
Delayed neurocognitive recovery	Digit symbol substitution test, TMT Part A, TMT Part B	Preoperative, postoperative day 5
Need of supplemental oxygen	L/min	During postanaesthesia care unit/ICU stay
Length of stay in ICU	Number of days at ICU	During ICU stay
Early PONV	Patient assessment of PONV episode	First 2 hours after surgery
Late PONV	Patient assessment of PONV episode	Evening on the day of surgery and morning and evening of the first five postoperative days
Intraoperative hypotension	Intraoperative mean arterial pressure+cumulative catecholamine administration	Intraoperative
Death within 5 days		First five postoperative days
Exploratory outcomes
Days at home up to 30 days after surgery (number of days at home in the first month after surgery)	Phone follow-Up, patient records	30 days after surgery
Long-term neurocognitive disorder	Montreal Cognitive Assessment test via phone follow-up	Preoperative, 1 year after surgery
AUC of inflammatory biomarkers	C reactive protein, interleukin-6, procalcitonin	Preoperative, within 2 hours after surgery, postoperative day 2
AUC of cardiac biomarkers	Troponin T, N-terminal probrain-natriuretic peptide, copeptin	Preoperative, within 2 hours after surgery, postoperative day 2
AUC of neuronal injury biomarkers	S100-B, neuron-specific enolase	Preoperative, within 2 hours after surgery, postoperative day 2
One-year all-cause mortality		One year after surgery
Substudy outcomes
Advanced neurobiomarkers	Neurofilament light chain, glial fibrillary acidic protein	Preoperative, postoperative day 3

AUC, area under the curve; CAM, confusion assessment method; ICU, intensive care unit; PONV, postoperative nausea and vomiting; TMT, trail making test.