Table 1

Characteristics of included papers synthesising expert views

CitationTrial-related contextCountry of the trial/contextTypeExpert backgroundLevel of evidence
37 Prophylactic antibiotics for neurosurgical procedure including clinical trialsUSAOpinionDoctor/researcher5
28 Trovafloxacine for meningitis in child trial
Target patient: Minors
Nigeria-KanoOpinionResearcher in sociology5
24 Phase IV clinical trials Target patient: Pregnant womenUSAOpinionDoctor/researcher5
26 The Closed or Open after Laparotomy (NCT03163095) Study (clinical trial for severe complicated intra-abdominal sepsis)CanadaOpinionDoctor/researcher5
31 Pragmatic trials for pneumoniaUSAOpinionDoctor/researcher5
36 Clinical trials for COVID-19 treatments and vaccinesInternationalOpinionDoctor/researcher5
47 Pharmacogenetics to Avoid Loss of Hearing trial (ISRCTN13704894) Target patient: Minors Consent giver: ParentsUKOpinionDoctor/researcher5
32 Phase 1/2 clinical trialsOpinionPharmacological researchers5
27 UKOpinionDoctor/researcher5
33 Evaluating Diuretics in Normal Care Study (ISRCTN46635087)
Cluster randomised trials of hypertension prescribing policy
Discussed consent mode: opt-in/out
UKOpinionDoctor/researcher5
51 Trials among stroke patientsUSAOpinionDoctor/researcher5
30 OpinionVeterinarian5
29 Clinical trials for Hospital-Acquired/Ventilator-Associated Bacterial PneumoniaUSAMeetings involving doctors and research staff in 2013An expert team of various stakeholders including academic scientists, clinicians, regulators, trial monitors and coordinators, and patient and industry representatives5
34 Clinical trials for COVID-19 treatments and vaccines
Target patient: Pregnant women
USAA public meeting involving doctors and research staff in 2021Stakeholder categories including academia, industry, governmental agencies and patient advocacy groups5
38 Noninferiority treatment trial for healthcare associated pneumonia Discussed consent mode: Advanced consentUSAInterviews and meetings involving health professionals, research staff and IRB members10 IRB representatives; 7 investigators; 5 study coordinators4
25 Noninferiority treatment trial for healthcare associated pneumonia Discussed consent mode: Advanced consentUSAInterviews and meetings involving doctors, research staff and IRB members during 2017–201810 IRB representatives; 7 investigators; 5 study coordinators4
43 CONservative TReatment of Appendicitis in Children a randomised controlled Trial (ISRCTN15830435) Target patient: Minors Consent giver: ParentsUKInterviews with doctors during 2017–201835 health professionals
(25 surgeons, 7 research nurses, 3 ward nurses)
4
35 Probiotics for Antibiotic Associated Diarrhoea study (ISRCTN 7954844)
Target patient: Older adults in care homes
Discussed consent mode: Advanced consent
UKInterviews with doctors and staff in 2013/201419 care home staff; 10 general practioners4
  • IRB, institutional review board.