Table 1

Schedule of enrolment, interventions and assessments for the trial

Study period
EnrolmentAllocationPostallocationFollow-up
Time point*1 day before surgery (T0)Surgery dayT1T2T3T4T5T6T7T8T9T101 day after surgery (F1)
Enrolment
Eligibility screenx
Informed consentx
Allocationx
Interventions
RemimazolamGraphic
PropofolGraphic
Assessments
Baseline variablesxx
Haemodynamic variablesxxxxxxxxxxx
Vasoactive drugs consumptionGraphic
The number of hypotension or hypertension episodesGraphic
The cumulative duration of hypotension or hypertensionGraphic
Rescue drug consumptionGraphic
Duration of extubation and awakening Graphic
Adverse event†Graphic

  • *T0: at ward (as baseline), T1: at intubation, T2: 15 min after intubation, T3: the beginning of surgery, T4-7: 15 min, 30 min, 60 min, 90 min after the beginning of surgery, T8: the end of surgery, T9: at extubation, T10: 10 min after extubation.

  • †Including hallucinations, agitation, delirium, hepatic and renal dysfunction, haematuria, nausea and vomiting, and so on.