Table 1

Overview of the outcome measurements at each study visit for DETECT

Outcome measurements	Evaluation tool	Baseline screening	DTM SCS
Outcome measurements	Evaluation tool	V0	V1 (1 month)	V2 (6 months)	V3 (12 months)
Overall pain	VAS	X	X	X	X
Leg pain intensity	VAS	X	X	X	X
Back pain intensity	VAS	X	X	X	X
Disability	ODI	X	X	X	X
Medication use	MQS III	X	X	X	X
Quality of life	EQ-5D-5L	X	X	X	X
Impression of change	PGIC		X	X	X
Patient activation	PAM-13	X	X	X	X
Holistic responder status	Composite measure		X	X	X
Pain catastrophising	PCS	X	X	X	X
Symptoms of central sensitisation	CSI	X	X	X	X
Anxiety and depression	HADS	X	X	X	X
Work status	Self-developed questionnaire	X		X	X
Patient expectations	Open question	X
Healthcare utilisation	Patient reporting		X	X	X
Time spent in body postures	IPG output		X	X	X
(Serious) adverse events	Physician reporting		X	X	X
Proportion of successful DTM trials			X
DTM stimulation parameters	IPG output		X	X	X
Battery consumption/recharge frequency	Patient reporting		X	X	X
Prevalence of technical issues with DTM programming	Physician reporting		X	X	X

CSI, Central Sensitization Inventory; DTM, differential target multiplexed; EQ-5D-5L, EuroQol with five dimensions and five levels; HADS, Hospital Anxiety and Depression Scale; IPG, implantable pulse generators; MQS III, Medication Quantification Scale III; MQS ODI, Oswestry disability index; PAM-13, Patient Activation Measure-13; PCS, Pain Catastrophizing Scale; PGIC, Patient Global Impression of Change Scale; SCS, spinal cord stimulation; V, visit; VAS, visual analogue scale.