Table 3

Association between the ACAG value and short-term all-cause mortality

	Crude model		Model I		Model II
	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value
28-day mortality (MIMIC-IV cohort)
ACAG (per one unit)	1.07 (1.06 to 1.09)	<0.001	1.08 (1.06 to 1.10)	<0.001	1.05 (1.03 to 1.07)	<0.001
Higher ACAG level	1.85 (1.48 to 2.32)	<0.001	1.90 (1.52 to 2.39)	<0.001	1.42 (1.11 to 1.83)	0.007
ICU mortality (MIMIC-IV cohort)
ACAG (per one unit)	1.06 (1.04 to 1.09)	<0.001	1.07 (1.05 to 1.09)	<0.001	1.04 (1.01 to 1.06)	0.005
Higher ACAG level	1.74 (1.33 to 2.28)	<0.001	1.87 (1.43 to 1.91)	<0.001	1.43 (1.05 to 1.93)	0.022
ICU mortality (eICU-CRD cohort)
ACAG (per one unit)	1.06 (1.04 to 1.08)	<0.001	1.07 (1.05 to 1.09)	<0.001	1.06 (1.03 to 1.09)	<0.001
Higher ACAG level	1.61 (1.22 to 2.11)	<0.001	1.65 (1.25 to 2.17)	<0.001	1.38 (1.02 to 1.86)	0.036
In-hospital mortality (MIMIC-IV cohort)
ACAG (per one unit)	1.06 (1.04 to 1.08)	<0.001	1.06 (1.04 to 1.08)	<0.001	1.04 (1.02 to 1.07)	<0.001
Higher ACAG level	1.51 (1.20 to 1.91)	<0.001	1.58 (1.25 to 2.01)	<0.001	1.31 (1.01 to 1.71)	0.041
In-hospital mortality (eICU-CRD cohort)
ACAG (per one unit)	1.06 (1.04 to 1.08)	<0.001	1.07 (1.05 to 1.09)	<0.001	1.05 (1.02 to 1.07)	<0.001
Higher ACAG level	1.81 (1.41 to 2.33)	<0.001	1.86 (1.44 to 2.39)	<0.001	1.47 (1.12 to 1.94)	0.006

Model I was adjusted for age, sex, race and weight/body mass index.
Model II was adjusted for age, sex, race, weight/body mass index, acute myocardial infarction, cardiomyopathy, atrial fibrillation, valvular heart disease, diabetes, chronic obstructive pulmonary disease, acute kidney injury, SOFA score, mean blood pressure, oxygen saturation, potassium, chloride, creatine and total bilirubin.
ACAG, albumin-corrected anion gap; HR, hazard ratio; CI, confidence interval.