ROC curve analysis of AG/ACAG values and short-term mortality
Factor | AUC | 95% CI | Cut-off | Sensitivity | Specificity | Youden’s index | |
ICU mortality (MIMIC-IV) | AG | 0.654 | 0.613 to 0.696 | 15.5 | 0.758 | 0.426 | 0.184 |
ACAG | 0.632 | 0.589 to 0.674 | 19.6 | 0.680 | 0.532 | 0.212 | |
ICU mortality (eICU-CRD) | AG | 0.594 | 0.546 to 0.642 | 18.1 | 0.526 | 0.654 | 0.180 |
ACAG | 0.613 | 0.566 to 0.660 | 25.4 | 0.351 | 0.857 | 0.208 | |
Hospital mortality (MIMIC-IV) | AG | 0.599 | 0.558 to 0.641 | 20.5 | 0.346 | 0.796 | 0.142 |
ACAG | 0.629 | 0.589 to 0.669 | 24.6 | 0.322 | 0.869 | 0.191 | |
Hospital mortality (eICU-CRD) | AG | 0.603 | 0.559 to 0.647 | 18.1 | 0.523 | 0.673 | 0.196 |
ACAG | 0.628 | 0.585 to 0.671 | 21.6 | 0.527 | 0.705 | 0.232 | |
28-day mortality (MIMIC-IV)) | AG | 0.614 | 0.574 to 0.654 | 21.5 | 0.295 | 0.870 | 0.165 |
ACAG | 0.641 | 0.602 to 0.680 | 22.9 | 0.400 | 0.805 | 0.205 |
AUC, area under curve; CI, confidence interval; AG, anion gap; ACAG, albumin-corrected anion gap.