Table 2

ROC curve analysis of AG/ACAG values and short-term mortality

	Factor	AUC	95% CI	Cut-off	Sensitivity	Specificity	Youden’s index
ICU mortality (MIMIC-IV)	AG	0.654	0.613 to 0.696	15.5	0.758	0.426	0.184
ICU mortality (MIMIC-IV)	ACAG	0.632	0.589 to 0.674	19.6	0.680	0.532	0.212
ICU mortality (eICU-CRD)	AG	0.594	0.546 to 0.642	18.1	0.526	0.654	0.180
ICU mortality (eICU-CRD)	ACAG	0.613	0.566 to 0.660	25.4	0.351	0.857	0.208
Hospital mortality (MIMIC-IV)	AG	0.599	0.558 to 0.641	20.5	0.346	0.796	0.142
Hospital mortality (MIMIC-IV)	ACAG	0.629	0.589 to 0.669	24.6	0.322	0.869	0.191
Hospital mortality (eICU-CRD)	AG	0.603	0.559 to 0.647	18.1	0.523	0.673	0.196
Hospital mortality (eICU-CRD)	ACAG	0.628	0.585 to 0.671	21.6	0.527	0.705	0.232
28-day mortality (MIMIC-IV))	AG	0.614	0.574 to 0.654	21.5	0.295	0.870	0.165
28-day mortality (MIMIC-IV))	ACAG	0.641	0.602 to 0.680	22.9	0.400	0.805	0.205

AUC, area under curve; CI, confidence interval; AG, anion gap; ACAG, albumin-corrected anion gap.