Study sites with annual number of eligible patients based on 2019 ICU volume
| Trauma centre | Location | Patients meeting study eligibility criteria | Stratification for randomisation |
| Harborview Medical Center (University of Washington) | Seattle, WA, USA | 702 | Very high |
| University of Alabama at Birmingham | Birmingham, AL, USA | 615 | Very high |
| Grady Memorial Hospital (Morehouse School of Medicine) | Atlanta, GA, USA | 583 | Very high |
| Lehigh Valley Health Network | Allentown, PA, USA | 507 | Very high |
| Rhode Island Hospital | Providence, RI, USA | 504 | High |
| Shock Trauma (University of Maryland Medical Center) | Baltimore, MD, USA | 398 | High |
| Froedtert Hospital (Medical College of Wisconsin) | Milwaukee, WI, USA | 321 | High |
| UC Davis Medical Center | Sacramento, CA, USA | 289 | High |
AL, Alabama; CA, California; GA, Georgia; ICU, intensive care unit; MD, Maryland; PA, Pennsylvania; RI, Rhode Island; WA, Washington; WI, Wisconsin.