Table 2

Evaluation of GRADE evidence quality

Outcome indicatorsMD, 95%CIRisk of biasInconsistencyIndirectnessImprecisionPublication biasUpgrade qualityQuality
SCP VD0.41 (–1.26 to 2.09)Serious*Serious†NoNoUndetectedNoneLow
DCP VD1.53 (0.62 to 2.44)Serious*NoNoNoUndetectedNoneModerate
FAZ0.01 (–0.01 to 0.03)Serious*NoNoNoUndetectedNoneModerate
CC VD0.76 (–1.11 to 2.64)Serious*Serious†NoNoUndetectedNoneLow
  • *Absence of allocation concealment and blinding.

  • †The p value of the heterogeneity test was <0.1 and I2>50%.

  • CC VD, choriocapillaris vascular density; DCP VD, deep capillary plexus VD; FAZ, foveal avascular zone; GRADE, Grading of Recommendations Assessment, Development and Evaluation; MD, mean difference; SCP VD, superficial capillary plexus VD.