Table 1

Measurement matrix

Study variablesMeasureData source
OutcomesVaccination ratesDid you receive the first dose, second dose and boosters of the COVID-19 vaccination: yes; no; not sure; skip.
EHR drug exposure with SARS-COV-2 (COVID-19) vaccination records.
AoU COVID-19 Vaccine Survey
& AoU EHR Drug exposures
Adverse reactionsAdverse reactions include swelling, fever, Guillain-Barre syndrome, headache, tiredness, muscle pain, chills, nausea, severe allergic reaction (anaphylaxis). AoU COVID-19 Vaccine Survey
Vaccine hesitancyWhen a COVID-19 vaccine is available, how likely are you to get vaccinated: very likely; likely; i do not know yet; unlikely; very unlikely; skip. AoU COVID-19 Vaccine Survey
CohortsADRD/MCI and non-ADRD/MCIICD-9/10 diagnosed conditions such as ‘mild cognitive impairment’ or ‘Alzheimer’s disease’ or ‘dementia’, or positive responses related to ADRD/MCI diagnosis in the EHR data. AoU EHR Conditions
Individual level factorsDemographicsAge, sex at birth, gender, race, ethnicity. AoU Basic Survey
Chronic conditionsChronic conditions related with ADRD/MCI and mental health status: hypertension, cerebrovascular disease, cerebral infarction, overweight and obesity, diabetes, coronary artery disease, heart failure, myocardial infarction, chronic obstructive pulmonary disease, chronic kidney disease, chronic liver disease, cancer, anxiety, major depressive disorder, bipolar disorder, psychotic disorder, sleep disorder AoU EHR Conditions
Interpersonal level factorsSociocultural environment and social supportLiving status, type of residence, household and neighbourhood environment, years of living at residency. AoU Social Determinants of Health Survey & AoU Basic Survey
Community level factorsHealthcare accessibility and utilisationHealthcare insurance coverage accepted by healthcare providers, place for healthcare services, number of visits for general doctors, nurse practitioners, physician assistants, obstetricians/gynaecologists, midwives, and reasons for delayed medical care. AoU Health Access & Utilization Survey
  • ADRD, Alzheimer’s disease and related dementias; AoU, All of Us; EHR, Electronic Health Record; MCI, mild cognitive impairment.