Table 1

Measurement matrix

	Study variables	Measure	Data source
Outcomes	Vaccination rates	Did you receive the first dose, second dose and boosters of the COVID-19 vaccination: yes; no; not sure; skip. EHR drug exposure with SARS-COV-2 (COVID-19) vaccination records.	AoU COVID-19 Vaccine Survey & AoU EHR Drug exposures
	Adverse reactions	Adverse reactions include swelling, fever, Guillain-Barre syndrome, headache, tiredness, muscle pain, chills, nausea, severe allergic reaction (anaphylaxis).	AoU COVID-19 Vaccine Survey
	Vaccine hesitancy	When a COVID-19 vaccine is available, how likely are you to get vaccinated: very likely; likely; i do not know yet; unlikely; very unlikely; skip.	AoU COVID-19 Vaccine Survey
Cohorts	ADRD/MCI and non-ADRD/MCI	ICD-9/10 diagnosed conditions such as ‘mild cognitive impairment’ or ‘Alzheimer’s disease’ or ‘dementia’, or positive responses related to ADRD/MCI diagnosis in the EHR data.	AoU EHR Conditions
Individual level factors	Demographics	Age, sex at birth, gender, race, ethnicity.	AoU Basic Survey
Individual level factors	Chronic conditions	Chronic conditions related with ADRD/MCI and mental health status: hypertension, cerebrovascular disease, cerebral infarction, overweight and obesity, diabetes, coronary artery disease, heart failure, myocardial infarction, chronic obstructive pulmonary disease, chronic kidney disease, chronic liver disease, cancer, anxiety, major depressive disorder, bipolar disorder, psychotic disorder, sleep disorder	AoU EHR Conditions
Interpersonal level factors	Sociocultural environment and social support	Living status, type of residence, household and neighbourhood environment, years of living at residency.	AoU Social Determinants of Health Survey & AoU Basic Survey
Community level factors	Healthcare accessibility and utilisation	Healthcare insurance coverage accepted by healthcare providers, place for healthcare services, number of visits for general doctors, nurse practitioners, physician assistants, obstetricians/gynaecologists, midwives, and reasons for delayed medical care.	AoU Health Access & Utilization Survey

ADRD, Alzheimer’s disease and related dementias; AoU, All of Us; EHR, Electronic Health Record; MCI, mild cognitive impairment.