Accuracy of MTB culture, Xpert MTB/RIF and nanopore sequencing for TBM diagnosis
| Test | Sensitivity% (95% CI) | Specificity% (95% CI) | PPV% (95% CI) | NPV% (95% CI) |
| MTB culture | 11.11 (3.71 to 24.05) | 100 (82.35 to 100.00) | 100 (47.82 to 100.00) | 32.20 (20.62 to 45.64) |
| Xpert MTB/RIF | 13.33 (5.05 to 26.79) | 100 (82.35 to 100.00) | 100 (54.07 to 100.00) | 32.76 (21.01 to 46.34) |
| Nanopore sequencing | 77.78 (62.91 to 88.80) | 100 (82.35 to 100.00) | 100 (90.00 to 100.00) | 65.52 (45.67 to 82.06) |
AFB, acid-fast bacillus; MTB, Mycobacterium tuberculosis; NPV, negative predictive value; PPV, positive predictive value; RIF, rifampicin.