Performance of biomarkers to discriminate sepsis from non-sepsis
| Variable | AUC (95% CI) | Cut-off value | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | P value |
| HBP | 0.733 (0.678 to 0.789) | 35.2 | 65.5 | 74.9 | 65.9 | 74.5 | |
| IL-6 | 0.658 (0.595 to 0.72) | 328.9 | 48.2 | 82.4 | 67.0 | 68.1 | 0.060 |
| WBC | 0.541 (0.474 to 0.607) | 21.0 | 20.1 | 95.7 | 77.8 | 61.7 | <0.001 |
| PCT | 0.812 (0.766 to 0.857) | 0.9 | 85.6 | 59.9 | 61.1 | 84.2 | 0.021 |
| CRP | 0.775 (0.724 to 0.827) | 107.7 | 66.9 | 77.0 | 68.4 | 75.8 | 0.237 |
| LAC | 0.632 (0.571 to 0.694) | 1.9 | 53.2 | 72.2 | 58.7 | 67.5 | 0.185 |
| APACHE II | 0.688 (0.630 to 0.747) | 12.5 | 65.5 | 63.6 | 64.3 | 64.8 | 0.128 |
| SOFA | 0.801 (0.755 to 0.848) | 4.5 | 83.5 | 62.0 | 68.7 | 79.0 | 0.064 |
The p values between AUCs compared with HBP.
APACHE II, acute physiology and chronic health evaluation II; AUC, area under the curve; CRP, C reactive protein; HBP, heparin-binding protein; IL-6, interleukin-6; LAC, blood lactic acid; NPV, negative predictive value; PCT, procalcitonin; PPV, positive predictive value; SOFA, Sequential Organ Failure Assessment; WBC, white blood cell count.