Table 3

GO MOMs primary, secondary and exploratory outcomes

Primary outcomesDefinition
Gestational diabetes mellitus100-gram 3-hour OGTT meeting Carpenter-Coustan criteria at 24w0d-28w0d gestation
Large for gestational ageBirth weight >90th percentile for gestational age according to Aris et al42
Secondary outcomes
 Hypertensive disorders of pregnancyIncludes pre-eclampsia with and without severe features, gestational hypertension, eclampsia, and haemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome
 Caesarean delivery
 Flank skinfoldEvaluated as a continuous measure and dichotomised as >90th percentile
 Small for gestational ageBirth weight <10th percentile for gestational age according to Aris et al42
 Preterm birthDelivery prior to estimated gestational age 37w0d
 Shoulder dystociaDefined clinically, requiring documentation that providers applied manoeuvres to reduce the shoulder at delivery
 Neonatal birth injuryBrachial plexus palsy or clavicular, humeral or skull fracture
 Neonatal hypoglycaemiaNeonatal hypoglycaemia requiring treatment
 Neonatal respiratory morbidityNeed for respiratory support within 72 hours after birth and consisting of one or more of the following: the use of continuous positive airway pressure (CPAP) or high-flow nasal cannula for at least two consecutive hours, supplemental oxygen with a fraction of inspired oxygen of at least 0.30 for at least four continuous hours, extracorporeal membrane oxygenation (ECMO) or mechanical ventilation. A high flow of air or blended air and oxygen is defined as more than 1 L/min
 Neonatal hyperbilirubinaemiaTreatment of hyperbilirubinaemia in the first week of life with phototherapy or exchange transfusion or a diagnosis of kernicterus
Exploratory outcomes
 NICU admissionAdmission to the NICU prior to hospital discharge
 Neonatal length of admission/length of stayIncludes NICU or entire delivery hospitalisation
 Spontaneous abortionPregnancy loss at <20w0d of gestation
 StillbirthIntrauterine fetal demise ≥20w0d of gestation
 Neonatal deathDeath within the first 28 days of life
 Major congenital malformationBirth defects that have significant medical, social or cosmetic consequences for the affected individual, and typically require medical intervention
 Antepartum admissions or maternal readmissionsAdmissions that occur after GO MOMs enrolment and up to 30 days following delivery
 Low Apgar scoreApgar score <7 at 5 min
  • d, days; GO MOMs, Glycemic Observation and Metabolic Outcomes in Mothers and Offspring; NICU, neonatal intensive care unit; OGTT, oral glucose tolerance test; w, weeks.