Cox proportional hazards models for effect of onychomycosis on primary and secondary outcome measures
| Outcome | Onychomycosis | Univariate model | Adjusted for antimycotic treatment | Multivariate model* | ||||
| Yes (%) | No (%) | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Primary | ||||||||
| Ulcer | 140 (5.1) | 2631 (94.9) | 1.37 (1.13 to 1.66) | 0.001 | 1.37 (1.13 to 1.66) | 0.001 | 1.23 (1.01 to 1.49) | 0.036 |
| Secondary | ||||||||
| Hospital referral | 186 (6.1) | 2874 (93.6) | 1.24 (1.02 to 1.52) | 0.035 | 1.27 (1.04 to 1.55) | 0.021 | 1.17 (0.96 to 1.43) | 0.128 |
| Surgical intervention | 427 (6.9) | 5722 (93.1) | 1.54 (1.35 to 1.75) | <0.001 | 1.46 (1.29 to 1.66) | <0.001 | 1.32 (1.16 to 1.51) | <0.001 |
| Cellulitis/erysipelas | 317 (6.5) | 4572 (93.5) | 1.48 (1.28 to 1.72) | <0.001 | 1.45 (1.25 to 1.68) | <0.001 | 1.27 (1.10 to 1.48) | 0.001 |
*Adjusted for: age, sex, peripheral arterial disease, venous insufficiency, ankle oedema, tinea pedis, psoriasis, lichen planus, eczema, neuropathy, smoking, antimycotic treatment (any).