Study flow chart
| Screen (<4 weeks) | Preoperative (≥1 week) | Postoperative (1–3 days) | Follow-up (1, 3 and 12 months) | |
| Informed consent | X | |||
| eMR review | X | X | X | X |
| Eligibility assessment | X | |||
| Sleep Questionnaires (PSQI, ESS, STOP-BANG, MEQ) | X | |||
| CAM evaluation | X | X | ||
| MoCA/t-MoCA | X | X | X | |
| PROMIS Questionnaires* | X | X | X | |
| Blood collection (AD genotyping and tau pathology) | X | X | ||
| Nutrition assessment | X | X | ||
| Actiwatch data collection (1 week) | X | X | ||
| ECG (PWV, AI) | X |
*Physical function (SF 8b V.1.2) and applied cognition abilities (SF 8a V.1.0) may only be evaluated during follow-up visits.
AD, Alzheimer’s disease; AI, augmentation index; CAM, Confusion Assessment Method; eMR, electronic medical record; ESS, Epworth Sleepiness Scale; MEQ, Morningness-Eveningness Questionnaire; MoCA/t-MoCA, (telephonic) Montreal Cognitive Assessment; PROMIS, Patient-Reported Outcomes Measurement Information System; PSQI, Pittsburg Sleep Quality Index; PWV, pulse wave velocity; SF, Short Form; STOP-BANG, snoring history, tired during the day, observed stop of breathing while sleeping, high blood pressure, BMI>35 kg/m2, age >50 years, neck circumference >40 cm and male gender.